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  3. Vimirogant

Vimirogant (Synonyms: VTP-43742)

Cat. No.: HY-103637
Handling Instructions

Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research.

For research use only. We do not sell to patients.

Vimirogant Chemical Structure

Vimirogant Chemical Structure

CAS No. : 1802706-04-2

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Description

Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2].

IC50 & Target[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC50)

In Vitro

Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

552.65

Formula

C₂₇H₃₅F₃N₄O₃S

CAS No.
SMILES

O=C(C1=CN=C([[email protected]](C(C)C)N(C[[email protected]]2CC[[email protected]](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VimirogantVTP-43742VTP43742VTP 43742RORRAR-related orphan receptorinflammatorycytokineIL-17ATh17cellsautoimmunedisorderspsoriasisarthritisPBMCInhibitorinhibitorinhibit

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Vimirogant
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HY-103637
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