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Cat. No.: HY-103637B

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Vimirogant hydrobromide

(Synonyms: VTP-43742 hydrobromide)

For research use only. We do not sell to patients.

CAS No.: 2115761-82-3
Formula: C₂₇H₃₇Br₂F₃N₄O₃S
Molecular Weight:714.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Vimirogant hydrobromide Chemical Structure

CAS No.: 2115761-82-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

IC₅₀ & Target^[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC₅₀)

All ROR Isoforms :

Chemical Information

CAS No. 2115761-82-3
Molecular Weight 714.48
Formula C₂₇H₃₇Br₂F₃N₄O₃S
SMILES

O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4.Br.Br
Synonyms

VTP-43742 hydrobromide
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gege C. RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345. Expert Opin Ther Pat. 2017;27(1):1-8. [Content Brief]

[2]. Gerard McGeehan, et al. VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945). J Immunol May 1, 2015, 194 (1 Supplement) 208.5-208.5.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Vimirogant hydrobromide

All ROR Isoforms