2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Endogenous Metabolite ROR
  4. Zymostenol

Zymostenol  (Synonyms: 5a-Cholest-8-en-3b-ol)

Cat. No.: HY-113345 Purity: ≥95.0%
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Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM).

For research use only. We do not sell to patients.

Zymostenol Chemical Structure

Zymostenol Chemical Structure

CAS No. : 566-97-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Zymostenol:

Zymostenol Related Antibodies

Top Publications Citing Use of Products

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RORγ RORα RORβ

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Description

Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM)[1][2][3].

IC50 & Target[1]

Human Endogenous Metabolite

 

RORγ

1 μM (EC50)

In Vitro

Zymostenol (12-104 μM) enhances the formation of myelin basic protein-positive (MBP+) oligodendrocytes from mouse epiblast stem cell-derived oligodendrocyte progenitor cells[2].
Zymostenol (20 μM, 3 days) arrest MCF-7 cell cycle in the G0-G1 phase[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zymostenol Related Antibodies

Cell Cycle Analysis[2]

Cell Line: MCF-7 cells
Concentration: 20 µM
Incubation Time: 3 days
Result: Induced 67 ± 1% accumulation of cells in the G0-G1 phase of the cell cycle.
Molecular Weight

386.65

Formula

C27H46O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C
Initial Source

human fibroblasts
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 3 mg/mL (7.76 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5863 mL 12.9316 mL 25.8632 mL
5 mM 0.5173 mL 2.5863 mL 5.1726 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.5863 mL 12.9316 mL 25.8632 mL 64.6580 mL
5 mM 0.5173 mL 2.5863 mL 5.1726 mL 12.9316 mL
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Zymostenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zymostenol566-97-25a-Cholest-8-en-3b-olEndogenous MetaboliteRORRAR-related orphan receptorMCF-7oligodendrocytecholesterolInhibitorinhibitorinhibit

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