566-97-2
566-97-2
Chemical Structure
Zymostenol
Synonym(s): 5a-Cholest-8-en-3b-ol
- CAS No.: 566-97-2
- Formula:C27H46O
- Molecular Weight:386.65
IUPAC Name: (3S,5S,10S,13R,14R,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: QETLKNDKQOXZRP-XTGBIJOFSA-N
SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C
Biological Activity: Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zymostenol | 99.33% | Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM). | ||||||||||||||||||||
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Zymostenol (Standard) | ≥98% | Zymostenol (Standard) (5a-Cholest-8-en-3b-ol (Standard)) is the analytical standard of Zymostenol (HY-113345). This product is intended for research and analytical applications. Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM). | ||||||||||||||||||||
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Zymostenol-d7 | 99.9% | Zymostenol-d7 is deuterium labeled 5a-Cholest-8-en-3b-ol. | ||||||||||||||||||||
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8-Dehydrocholesterol | 95.61% | 8-Dehydrocholesterol elevated concentration is one of the diagnostic biochemical hallmarks of classical Smith-Lemli-Opitz syndrome (SLOS). | ||||||||||||||||||||
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Lathosterol (Standard) | 96.91% | Lathosterol (Standard) is the analytical standard of Lathosterol (HY-113486). This product is intended for research and analytical applications. Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury. | ||||||||||||||||||||
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Zymosterol | 99.94% | Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell. | ||||||||||||||||||||
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24S,25-Epoxyzymosterol | 24S,25-Epoxyzymosterol is an oxysterol. | |||||||||||||||||||||
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4α-Methylfecosterol | 4α-Methylfecosterol is an unsaponifiable lipid. | |||||||||||||||||||||
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α-Ergostenol | 99.97% | α-Ergostenol (Ergost-8(14)-en-3-ol) is a phytosterol isolated from the fruits of Cirsium palustre and C. rivulare. | ||||||||||||||||||||
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Dihydro T-MAS | Demethyldihydrolanosterol belongs to the class of sterols and is a derivative of lanosterol. Demethyldihydrolanosterol can be studied in research on cholesterol biosynthesis and the development of pharmaceuticals targeting cholesterol-related pathways. | |||||||||||||||||||||
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15α-Hydroxycholestene | 15α-Hydroxycholestene is an oxysterol. | |||||||||||||||||||||
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15β-Hydroxycholestene | 15β-Hydroxycholestene is an oxysterol. | |||||||||||||||||||||
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5α-Cholesta-8,14-dien-3β-ol | 5α-Cholesta-8,14-dien-3β-ol is an efficient precursor of cholesterol, which converts to cholesterol under aerobic conditions. 5α-Cholesta-8,14-dien-3β-ol can be used for metabolic research. | |||||||||||||||||||||
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References
- [1]. Hu X, et al. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists. Nat Chem Biol. 2015 Feb;11(2):141-7. [Content Brief]
- [2]. Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560(7718):372-376. [Content Brief]
- [3]. Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008 Dec;7(12):3707-18. [Content Brief]
