1. Immunology/Inflammation
  2. COX
  3. Phenylbutazone

Phenylbutazone 

Cat. No.: HY-B0230 Purity: 99.94%
Handling Instructions

Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

For research use only. We do not sell to patients.

Phenylbutazone Chemical Structure

Phenylbutazone Chemical Structure

CAS No. : 50-33-9

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

In Vitro

Phenylbutazone has low inhibition of COX-1 and COX-2[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.37

Formula

C₁₉H₂₀N₂O₂

CAS No.

50-33-9

SMILES

O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (324.29 mM)

H2O : 0.67 mg/mL (2.17 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2429 mL 16.2143 mL 32.4286 mL
5 mM 0.6486 mL 3.2429 mL 6.4857 mL
10 mM 0.3243 mL 1.6214 mL 3.2429 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PhenylbutazoneCOXCyclooxygenaseprostaglandinHsynthasePHShepatotoxinNSAIDMBNL1ankylosingspondylitisInhibitorinhibitorinhibit

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Product Name:
Phenylbutazone
Cat. No.:
HY-B0230
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