1. Immunology/Inflammation
  2. COX
  3. Phenylbutazone

Phenylbutazone 

Cat. No.: HY-B0230 Purity: 98.86%
Handling Instructions

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.

For research use only. We do not sell to patients.

Phenylbutazone Chemical Structure

Phenylbutazone Chemical Structure

CAS No. : 50-33-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 60 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. Target: Others Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, when combined with paracetamol and many other household painkillers even in the smallest doses can cause irreversible liver degradation proving fatal in many cases. It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable. Phenylbutazone may be administered orally (via paste, powder or feed-in) or intravenously. It should not be given intramuscularly or injected in any place other than a vein, as it can cause tissue damage. Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. Phenylbutazone should be administered only under the advice of a veterinarian.

IC50 & Target

COX-2

1.1 μM (IC50)

COX-1

3.7 μM (IC50)

Molecular Weight

308.37

Formula

C₁₉H₂₀N₂O₂

CAS No.

50-33-9

SMILES

O=C(C1CCCC)N(C2=CC=CC=C2)N(C3=CC=CC=C3)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (324.29 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2429 mL 16.2143 mL 32.4286 mL
5 mM 0.6486 mL 3.2429 mL 6.4857 mL
10 mM 0.3243 mL 1.6214 mL 3.2429 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PhenylbutazoneCOXCyclooxygenaseInhibitorinhibitorinhibit

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Phenylbutazone
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HY-B0230
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