Phenylbutazone-13C12
Based on 1 Customer Validation
Phenylbutazone-13C12 is the 13C12 labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 1325559-13-4
- Formula: C713C12H20N2O2
- Molecular Weight:320.29
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1325559-13-4
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Unlabeled Cas 50-33-9
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Appearance Solid
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Molecular Weight 320.29
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Formula C713C12H20N2O2
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Color White to off-white
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SMILES
O=C1N([13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)N([13C]3=[13CH][13CH]=[13CH][13CH]=[13CH]3)C(C1CCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (312.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.67 mg/mL (2.09 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (648 KB)
- English - EN (648 KB)
- Français - FR (648 KB)
- Deutsch - DE (648 KB)
- Norwegian - NO (648 KB)
- Español - ES (648 KB)
- Swedish - SV (648 KB)
- Italian - IT (648 KB)
- Korean - KR (648 KB)
- Portuguese - PT (648 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. G A Reed, et al. Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14. [Content Brief]
[3]. Guiying Chen, et al. Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy. Sci Rep. 2016 Apr 29;6:25317. [Content Brief]
[4]. Beretta C, et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.1222 mL | 15.6109 mL | 31.2217 mL | 78.0543 mL |
| DMSO | 5 mM | 0.6244 mL | 3.1222 mL | 6.2443 mL | 15.6109 mL |
| 10 mM | 0.3122 mL | 1.5611 mL | 3.1222 mL | 7.8054 mL | |
| 15 mM | 0.2081 mL | 1.0407 mL | 2.0814 mL | 5.2036 mL | |
| 20 mM | 0.1561 mL | 0.7805 mL | 1.5611 mL | 3.9027 mL | |
| 25 mM | 0.1249 mL | 0.6244 mL | 1.2489 mL | 3.1222 mL | |
| 30 mM | 0.1041 mL | 0.5204 mL | 1.0407 mL | 2.6018 mL | |
| 40 mM | 0.0781 mL | 0.3903 mL | 0.7805 mL | 1.9514 mL | |
| 50 mM | 0.0624 mL | 0.3122 mL | 0.6244 mL | 1.5611 mL | |
| 60 mM | 0.0520 mL | 0.2602 mL | 0.5204 mL | 1.3009 mL | |
| 80 mM | 0.0390 mL | 0.1951 mL | 0.3903 mL | 0.9757 mL | |
| 100 mM | 0.0312 mL | 0.1561 mL | 0.3122 mL | 0.7805 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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