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Results for "

oligodendrocyte

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine β-hydroxylase (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Fluorescent Dye (1) Phosphatase (1) PKC (1) ROR (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (10)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Targets Recommended: OLIG2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113345

Zymostenol 5a-Cholest-8-en-3b-ol	Endogenous Metabolite ROR	Cancer
Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC₅₀: 1 μM) .

HY-136490

Psychosine Galactosylsphingosine	PKC	Neurological Disease Cancer
Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease . Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC .

HY-100670

Olinone	Epigenetic Reader Domain	Neurological Disease
Olinone is a selective BRD4 BrD1 inhibitor . Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation .

HY-162351

EBP-IN-1	Others	Metabolic Disease
EBP-IN-1 (compound 11) is an inhibitor of emopamil-binding protein (EBP), a sterol isomerase in the cholesterol biosynthetic pathway. EBP-IN-1 has a long half-life in rodents and has good metabolic turnover and brain penetration properties. EBP-IN-1 enhances oligodendrocyte formation in human cortical organoids .

HY-135749

BN201	Others	Neurological Disease Inflammation/Immunology
BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes (EC₅₀ of 6.3 μM) in vitro, and the myelination of new axons (EC₅₀ of 16.6 μM). BN201 is able to cross the blood-brain barrier by active transport and activate pathways (IGF-1 pathway) associated with the response to stress and neuron survival. BN201 has potently neuroprotective effects .

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

HY-P5982

PTPσ Inhibitor, ISP	Phosphatase	Neurological Disease
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .

HY-W115718

Cuprizone 1 Publications Verification	Dopamine β-hydroxylase	Neurological Disease
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .

Cat. No.	Product Name	Target	Research Area

HY-P1240

*Myelin Oligodendrocyte* Glycoprotein Peptide (35-55), mouse, rat** 4 Publications Verification MOG (35-55)	Peptides	Neurological Disease Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .

HY-P1240B

*Myelin Oligodendrocyte* Glycoprotein Peptide (35-55), mouse, rat acetate** 4 Publications Verification MOG (35-55) (acetate)	Peptides	Neurological Disease Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) acetate is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .

HY-P1240A

*Myelin Oligodendrocyte* Glycoprotein Peptide (35-55), mouse, rat TFA** 4 Publications Verification MOG (35-55) (TFA)	Peptides	Neurological Disease Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .

HY-P5966

*Myelin Oligodendrocyte* Glycoprotein (40-54), Rat, Mouse** MOG (40-54)	Peptides	Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db .

HY-P2461

MOG (89-113), human

Peptides Neurological Disease

MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.
HY-P3718

MOG peptide (79-96) rat

Peptides Inflammation/Immunology

MOG peptide (79-96) rat is a myelin oligodendrocyte glycoprotein (MOG) with encephalitogenic effects .

MOG (89-113), human	Peptides	Neurological Disease
MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.

MOG peptide (79-96) rat	Peptides	Inflammation/Immunology
MOG peptide (79-96) rat is a myelin oligodendrocyte glycoprotein (MOG) with encephalitogenic effects .

HY-P3719

MOG peptide (35-55)	Peptides	Inflammation/Immunology
MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide. MOG peptide (35-55) is specific to expanded CD4 ⁺ T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model .

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

HY-P1242A

NEP(1-40) TFA	Peptides	Inflammation/Immunology
NEP(1-40) TFA is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition .

HY-P1242

NEP(1-40) 1 Publications Verification	Peptides	Inflammation/Immunology
NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition .

HY-P5448

MOG (92–106), mouse, rat	Peptides	Others
MOG (92–106), mouse, rat is a biological active peptide. (This is amino acids 92 to 106 fragment of the myelin oligodendrocyte glycoprotein (MOG) from mouse/rat. Mice with MOG (92–106)-induced experimental autoimmune encephalomyelitis develop extensive B cell reactivity against secondary myelin antigens. Despite the fact that this MOG peptide induces only weak T cell responses, MOG-induced autoimmunity is very severe. This peptide is encephalitogenic in SJL mice, DA rats, and rhesus monkeys.)

HY-P5982

PTPσ Inhibitor, ISP	Phosphatase	Neurological Disease
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .

Species:	Human (3) Mouse (3)
Tag:	His (6)
Source:	HEK293 (3) E. coli Cell-free (1) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70845

	MOG Protein, Human (HEK293, His) Myelin-oligodendrocyte Glycoprotein; MOG	Human	HEK293
	MOG proteins play a key role in homogeneous cell-to-cell adhesion, promoting important junctions. As a minor but integral component of myelin, it contributes to its underlying completion and maintenance. MOG Protein, Human (HEK293, His) is the recombinant human-derived MOG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MOG Protein, Human (HEK293, His) is 125 a.a., with molecular weight of 18-25 kDa.

HY-P76527

	OMGP Protein, Mouse (HEK293, His) oligodendrocyte-myelin glycoprotein; OMG	Mouse	HEK293
	OMGP protein is a cell adhesion molecule that plays a crucial role in the interactive process necessary for myelination in the central nervous system. It accomplishes this by binding to RTN4R, facilitating the formation and maintenance of myelin sheaths. OMGP Protein, Mouse (HEK293, His) is the recombinant mouse-derived OMGP protein, expressed by HEK293 , with C-His labeled tag. The total length of OMGP Protein, Mouse (HEK293, His) is 221 a.a., with molecular weight of ~44 KDa.

HY-P75948

	OMGP Protein, Human (HEK293, His) oligodendrocyte-myelin glycoprotein; OMG; OMGP	Human	HEK293
	The OMGP protein is a cell adhesion molecule that plays a crucial role in the complex myelination process in the central nervous system. Its function involves binding to RTN4R, which facilitates molecular interactions required for fundamental steps in myelination. OMGP Protein, Human (HEK293, His) is the recombinant human-derived OMGP protein, expressed by HEK293 , with C-His labeled tag. The total length of OMGP Protein, Human (HEK293, His) is 416 a.a., with molecular weight of 120-130 kDa.

HY-P702246

	CLDN11 Protein, Human (Cell-Free, His) Claudin-11; oligodendrocyte-specific protein	Human	E. coli Cell-free
	Claudin-11/CLDN11 Protein plays a crucial role in tightly closing intercellular spaces in tight junctions, facilitated by its calcium-independent cell-adhesion capabilities. Interacting with tetraspanin-3/TSPAN3 suggests potential collaboration in cellular processes. CLDN11's associations with OCLN highlight its involvement in molecular interactions, contributing to the structural integrity and functional regulation of tight junctions. CLDN11 Protein, Human (Cell-Free, His) is the recombinant human-derived CLDN11 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CLDN11 Protein, Human (Cell-Free, His) is 207 a.a., with molecular weight of 23.5 kDa.

HY-P702768

	MOG Protein, Mouse (N-His) Myelin-oligodendrocyte glycoprotein; Mog; MOGIG2	Mouse	E. coli
	MOG Protein potentially finalizes and maintains the myelin sheath, contributing to cell-cell communication. It acts as a homophilic cell adhesion molecule, mediating cellular interactions through homodimerization, indicating its involvement in establishing connections within myelin-related processes. MOG Protein, Mouse (N-His) is the recombinant mouse-derived MOG protein, expressed by E. coli , with N-His labeled tag.

HY-P702767

	MOG Protein, Mouse (P.pastoris, His) Myelin-oligodendrocyte glycoprotein; Mog; MOGIG2	Mouse	P. pastoris
	MOG Protein potentially finalizes and maintains the myelin sheath, contributing to cell-cell communication. It acts as a homophilic cell adhesion molecule, mediating cellular interactions through homodimerization, indicating its involvement in establishing connections within myelin-related processes. MOG Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived MOG protein, expressed by P. pastoris , with C-His labeled tag. The total length of MOG Protein, Mouse (P.pastoris, His) is 128 a.a., with molecular weight of ~16.1 kDa.


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