MOG (35-55) mouse, rat (Synonyms: Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat)

Name: MOG (35-55) mouse, rat
Brand: MedChemExpress
SKU: HY-P1240
Rating: 5.0 (9 reviews)

Cat. No.: HY-P1240 Purity: 99.73%: Data Sheet
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MOG (35-55) mouse, rat (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) is a minor component of CNS myelin. MOG (35-55) mouse, rat has encephalitogenic activity and induces T cell proliferative. MOG (35-55) mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) mouse, rat (MOG (35-55)) can be used for experimental autoimmune encephalomyelitis (EAE) modeling.

For research use only. We do not sell to patients.

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CAS No. : 149635-73-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 9 publication(s) in Google Scholar

Other Forms of MOG (35-55) mouse, rat:

MOG (35-55) TFA In-stock
MOG (35-55) acetate In-stock

9 Publications Citing Use of MCE MOG (35-55) mouse, rat

Others

Cell Proliferation/Viability Assay

Histological Imaging/Staining

ELISA

Flow Cytometry

: MOG (35-55) mouse, rat purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2025 Sep 29. [Abstract]; Scheme of the EAE Adoptive Transfer Model: Mice underwent immunization via subcutaneous injection of MOG35–55 in complete Freund’s adjuvant. Ten days post-immunization, spleens were harvested, and single-cell suspensions were prepared. These splenocytes were treated for 3 days with IL-12, IL-23, and anti-IFN-γ. Subsequently, the splenocytes were subjected to a 3-day treatment with 1 μM PAPTP, or left untreated. Antigen-specificity of the cells was confirmed by additional proliferation assays of isolated donor lymphocytes (see Methods). Lymphocytes were isolated, and the induction of apoptosis was assessed using flow cytometry. Additionally, these lymphocytes were transferred into wild-type recipient animals, and the animals’ clinical scores were monitored daily for 10 days. Following the observation period, the animals were euthanized for further analysis.

: MOG (35-55) mouse, rat purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2025 Sep 29. [Abstract]; Representative image (of 5 sections) of brains (upper part of the pons region) stained with PE-anti-CD45, from wild-type mice intraperitoneally injected with either untreated or PAPTP 1 μM treated, MOG35–55 activated lymphocytes.3J

: MOG (35-55) mouse, rat purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2025 Sep 29. [Abstract]; Treatment scheme for wild-type mice immunized via subcutaneous injection of MOG35–55: upon the manifestation of initial symptoms, typically around day 10 post-immunization, treatment commenced. The treatment regimen was administered every 48 h, totaling 11 injections. Mice were euthanized the day following the final injection for subsequent analysis of peripheral blood, brains, and spinal cords.

: MOG (35-55) mouse, rat purchased from MedChemExpress. Usage Cited in: Front Biosci (Landmark Ed). 2025 May 23;30(5):37838. [Abstract]; The BV-2 cells were cultured in designated concentrations of MOG35-55 (0-25μg/mL, 24 h). MTT analysis of BV-2 cell viability.

: MOG (35-55) mouse, rat purchased from MedChemExpress. Usage Cited in: Front Biosci (Landmark Ed). 2025 May 23;30(5):37838. [Abstract]; The BV-2 cells were cultured in designated concentrations of MOG35-55 (0-25μg/mL, 24 h). ELISA analysis of the release of HMGB1.

: MOG (35-55) mouse, rat purchased from MedChemExpress. Usage Cited in: Front Biosci (Landmark Ed). 2025 May 23;30(5):37838. [Abstract]; The BV-2 cells were cultured in designated concentrations of MOG35-55 (0-25μg/mL). Cytometry analysis for CD11b⁺ and CD68⁺ cells.

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Description

In Vitro

MOG (35-55) mouse, rat (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat); 0-50 μg/mL; 72 h; lymph nodes cells) induces T cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. MOG (35-55) mouse, rat increases the level of IgG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 is one of the targets of self-reactive T cell responses, leading to acute and later chronic autoimmune processes. MOG 35-55 is capable of inducing experimental autoimmune encephalomyelitis (EAE) in B6 mice^[1].

Induction of experimental autoimmune encephalomyelitis (EAE) model^[3]

Background

Myelin Oligodendrocyte Glycoprotein Peptide (35-55) CAN trigger an immune response against the CNS, and induces inflammation and destruction of myelin or antigen-bearing structures that causes neurological abnormalities.

Specific Modeling Methods

Mice: C57BL/6 background mice • 2-4 months old • male and female
Administration: On day 0: 3 mg/mL peptide plus CFA (4 mg/mL) • Mix thoroughly 1: 1 peptide and CFA solutions • s.c. • 100 μL for each hind flank; • On day 0 and day 2: 2.5 μg/mL of Bordetella pertussis toxin • i.p. • 200 μL

Note

1. Once peptide and CFA emulsion is formed, it can be stored at 4 °C for a few hours or used immediately.
2. Symptoms appear approximately 10-15 days after immunization.
3. When mice have clinical symptoms of EAE, hydrated food is placed on the cage floor to facilitate access to these mice.
4. Record parameters every other day at the beginning, and daily from 7th postimmunization day. Body weight decreases usually precedes EAE clinical signs and is a very objective and valuable measure.

Modeling Indicators

Evaluate changes in body weight and clinical scoring: body weight loss, loss of tail tonus, paralyzed tail, hind limb paraparesis, hind limb paralysis, front leg paralysis, tetraplegia, moribund, etc.
prototypical histopathological changes: Luxol fast blue staining of spinal cord for myelin evaluation shows infiltrates and demyelination in EAE animals.

Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HLA-DR2 (DRB1*1501) mice^[1]
Dosage:	200 μg (0.2 mL)
Administration:	Intraperitoneal injection; once, for 38 days
Result:	Resulted in paralysis of both hind and forelimbs.

Molecular Weight

2581.95

Formula

C₁₁₈H₁₇₇N₃₅O₂₉S

CAS No.

149635-73-4

Appearance

Solid

Color

White to off-white

Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (38.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3873 mL	1.9365 mL	3.8730 mL
5 mM	0.0775 mL	0.3873 mL	0.7746 mL
10 mM	0.0387 mL	0.1937 mL	0.3873 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (284 KB) SDS (252 KB)

COA (252 KB) RP-HPLC (263 KB) MS (240 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)

References

[1]. Rich C, et, al. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol. 2004 May;34(5):1251-61. [Content Brief]

[2]. Slavin A, et, al. Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity. 1998;28(2):109-20. [Content Brief]

[3]. Giralt M, et, al. Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse. Methods Mol Biol. 2018;1791:227-232. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3873 mL	1.9365 mL	3.8730 mL	9.6826 mL
	5 mM	0.0775 mL	0.3873 mL	0.7746 mL	1.9365 mL
	10 mM	0.0387 mL	0.1937 mL	0.3873 mL	0.9683 mL
	15 mM	0.0258 mL	0.1291 mL	0.2582 mL	0.6455 mL
	20 mM	0.0194 mL	0.0968 mL	0.1937 mL	0.4841 mL
	25 mM	0.0155 mL	0.0775 mL	0.1549 mL	0.3873 mL
	30 mM	0.0129 mL	0.0646 mL	0.1291 mL	0.3228 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

MOG (35-55) mouse, rat Related Classifications

Neurological Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOG (35-55) mouse, rat149635-73-4Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, ratEndogenous MetaboliteautoantigenicdemyelinatingplaqueautoimmunityInhibitorinhibitorinhibit

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MOG (35-55) mouse, rat (Synonyms: Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat)

Customer Review

Other Forms of MOG (35-55) mouse, rat:

MOG (35-55) mouse, rat Related Antibodies

9 Publications Citing Use of MCE MOG (35-55) mouse, rat

Featured Recommendations

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•Related Small Molecules:

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View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

MOG (35-55) mouse, rat Related Antibodies

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Complete Stock Solution Preparation Table

MOG (35-55) mouse, rat Related Classifications

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