Incomplete Freund's adjuvant (IFA)
Based on 9 publication(s) in Google Scholar
Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response.
For research use only. We do not sell to patients.
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Storage:
Store at 4°C, do not freeze
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Incomplete Freund's adjuvant (IFA)
More- Cell. 2026 May 28;189(11):3432-3443.e16. [Abstract]
- Adv Funct Mater. 2025 Mar 10.
- Cell Commun Signal. 2025 Jan 7;23(1):8. [Abstract]
- Mater Today Bio. 2025 Jul 10:33:102074. [Abstract]
- J Funct Biomater. 2026 May 6;17(5):228. [Abstract]
- Int J Mol Sci. 2026 May 11;27(10):4270. [Abstract]
- Viruses. 2026 May 21;18(5):579. [Abstract]
- J Pharm Biomed Anal. 2026 Aug 15:276:117465. [Abstract]
- Gen Comp Endocrinol. 2026 May 12;381:114947.
Biological Activity
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Incomplete Freund's adjuvant (IFA) can be used to create experimental autoimmune myocarditis models, with a relatively low plasma clearance rate of 22%[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Incomplete Freund's adjuvant (IFA)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at 4°C, do not freeze
Publications (9)
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Journal Impact Factor
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Most Recent
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Cell
2026 May 28;189(11):3432-3443.e16. PMID: 41980782 -
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Cell Commun Signal
Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms. [Abstract]2025 Jan 7;23(1):8. PMID: 39762855 -
Mater Today Bio
Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization. [Abstract]2025 Jul 10:33:102074. PMID: 40688667 -
J Funct Biomater
Therapeutic Efficacy of Dual-Targeting Nanoparticles with Low Immunogenicity in the Treatment of Rheumatoid Arthritis. [Abstract]2026 May 6;17(5):228. PMID: 42188395 -
Int J Mol Sci
Establishment of an Autoimmune Premature Ovarian Insufficiency Mouse Model with Proteomic Analyses: An Exploratory Study. [Abstract]2026 May 11;27(10):4270. PMID: 42196258 -
Viruses
Aerosol Inhalation of a Recombinant H7N9 Hemagglutinin Antigen Elicits Systemic and Mucosal Immune Responses in Mice. [Abstract]2026 May 21;18(5):579. PMID: 42198780 -
J Pharm Biomed Anal
Study of GJKBW against RA based on the Chinmedomics combined LIP-MS molecular fishing technology: A new strategy for discovering the therapeutic material basis. [Abstract]2026 Aug 15:276:117465. PMID: 41875839 -
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Melssen MM, et al. Peptide emulsions in incomplete Freund's adjuvant create effective nurseries promoting egress of systemic CD4+ and CD8+ T cells for immunotherapy of cancer. J Immunother Cancer. 2022 Sep;10(9):e004709. [Content Brief]
[2]. Fontes JA, et al. Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. Immun Inflamm Dis. 2017 Jun;5(2):163-176. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Incomplete Freund's adjuvant (IFA) Related Classifications
HY-153808A Related Classifications
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- Incomplete Freund's adjuvant (IFA)
- Bacterial
- immunologic adjuvant
- immunity
- inflammation
- immunization-induced animal models
- collagen-induced arthritis
- CIA
- experimental autoimmune encephalomyelitis
- EAE
- experimental autoimmune thyroiditis
- EAT
- experimental autoimmune uveitis
- EAU
- experimental autoimmune myocarditis
- EAM
- Inhibitor
- inhibitor
- inhibit