Complete Freund's adjuvant (CFA, 1 mg/ml)
Based on 1 Customer Validation
Complete Freund's adjuvant (CFA, 1 mg/ml) is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA, 1 mg/ml) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA, 1 mg/ml) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA, 1 mg/ml) stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more.
For research use only. We do not sell to patients.
- CAS No.: 9007-81-2
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Storage:
Store at 4°C, do not freeze
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Complete Freund's adjuvant (1 mg/ml, 0.1 mL; s.c.; once a day for two days) can be used to induce rheumatoid arthritis in Sprague-Dawley rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[3]
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Dosage:1 mg/ml, 0.1 mL
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Administration:s.c.; once a day for two days
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Result:Increased the index of thymus and spleen.
Decreased the activities of GSH, CAT, SOD and MPO.
Increased the level of IL-1β, IL-6, IL-17, MCP-1, TNF-α, COX-2, 5-LOX, NF-p65, IgG1 and IgG2a.
Reduced level of IL-10.
Chemical Information
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CAS No. 9007-81-2
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Complete Freund's adjuvant (CFA, 1 mg/ml)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at 4°C, do not freeze
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Fontes JA, et al. Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. Immun Inflamm Dis. 2017 Jun;5(2):163-176. [Content Brief]
[2]. Ji YW, et al. Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice. Nat Commun. 2023 Apr 17;14(1):2182. [Content Brief]
[3]. Weng W, et al. Protective effect of Corynoline on the CFA induced Rheumatoid arthritis via attenuation of oxidative and inflammatory mediators. Mol Cell Biochem. 2021 Feb;476(2):831-839. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Freund's adjuvant (CFA, 1 mg/ml) Related Classifications
HY-153808B Related Classifications
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