1. Stem Cell/Wnt
  2. Wnt
  3. IWR-1

IWR-1 (Synonyms: endo-IWR 1; IWR-1-endo)

Cat. No.: HY-12238 Purity: 99.18%
Handling Instructions

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

For research use only. We do not sell to patients.

IWR-1 Chemical Structure

IWR-1 Chemical Structure

CAS No. : 1127442-82-3

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 92 In-stock
Estimated Time of Arrival: December 31
50 mg USD 414 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products

    IWR-1 purchased from MCE. Usage Cited in: Oncol Rep. 2018 Aug;40(2):877-886.

    IWR-1 induces cell differentiation. (A) NB4 and (B) HL-60 cells are treated with 0 (DMSO), 5 and 10 μM IWR-1 for three days, and the expression of β-catenin and differentiation marker CD11b is assessed by western blotting.

    IWR-1 purchased from MCE. Usage Cited in: Cell Biol Int. 2017 May;41(5):534-543.

    SCAPs are cultured with modified neural differentiation medium for the indicated time periods. The neuron-like cells in control group, SFRP2 over-expressed group and 10 uM IWR1-endo treated group are positive for βIII-tubulin (red) expression by using immunofluorescence staining.
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    Description

    IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

    IC50 & Target

    IC50: 180 nM (Wnt)

    In Vitro

    Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly[1]. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage[2]. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 µM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression[3].

    Molecular Weight

    409.44

    Formula

    C₂₅H₁₉N₃O₃

    CAS No.

    1127442-82-3

    SMILES

    O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([[email protected]]4([H])[[email protected]](C5)([H])C=C[[email protected]]5([H])[[email protected]]64[H])=O)C6=O)C=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 46 mg/mL (112.35 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4424 mL 12.2118 mL 24.4236 mL
    5 mM 0.4885 mL 2.4424 mL 4.8847 mL
    10 mM 0.2442 mL 1.2212 mL 2.4424 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.11 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.18%

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    Keywords:

    IWR-1endo-IWR 1IWR-1-endoIWR1IWR 1WntInhibitorinhibitorinhibit

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    Product Name:
    IWR-1
    Cat. No.:
    HY-12238
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