Z-DEVD-FMK
Based on 138 publication(s) in Google Scholar
Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 210344-95-9
- Formula: C30H41FN4O12
- Molecular Weight:668.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Publications Citing Use of MedChemExpress (MCE) Z-DEVD-FMK
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Signal Transduct Target Ther. 2024 Feb 28;9(1):43. [Abstract]
- Cell. 2024 Feb 1;187(3):624-641.e23. [Abstract]
- Immunity. 2024 Dec 10;57(12):2737-2754.e12. [Abstract]
- Blood. 2026 Jan 20:blood.2025028733. [Abstract]
- Cell Mol Immunol. 2021 Jan;18(1):219-229. [Abstract]
- Autophagy. 2026 Jun;22(6):1287-1305. [Abstract]
- Autophagy. 2026 Jan 19:1-16. [Abstract]
- Nat Commun. 2025 Jun 2;16(1):5126. [Abstract]
- Nat Commun. 2025 Jan 31;16(1):1233. [Abstract]
- Nat Commun. 2021 Nov 22;12(1):6786. [Abstract]
- J Adv Res. 2025 Jan 25:S2090-1232(25)00059-1. [Abstract]
- Neuron. 2024 Oct 23;112(20):3452-3469.e9. [Abstract]
- J Nanobiotechnology. 2025 Mar 28;23(1):252. [Abstract]
- J Nanobiotechnology. 2022 Jan 20;20(1):37. [Abstract]
- Genes Dis. 2026 Jun 15.
- Biomark Res. 2025 Jan 9;13(1):8. [Abstract]
- Acta Pharm Sin B. 2023 Oct;13(10):4253-4272. [Abstract]
- Acta Pharm Sin B. 2020 Aug;10(8):1397-1413. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(21):e14863. [Abstract]
- Adv Sci (Weinh). 2026 Mar 18:e74886. [Abstract]
- Adv Sci (Weinh). 2025 Aug 7:e09208. [Abstract]
- Cell Rep Med. 2026 Jan 20;7(1):102537. [Abstract]
- Cell Death Differ. 2026 Apr 4. [Abstract]
- Neuro Oncol. 2023 Oct 3;25(10):1788-1801. [Abstract]
- J Control Release. 2026 Jun 18:396:115116. [Abstract]
- J Control Release. 2026 Feb 27:114750. [Abstract]
- Cell Death Dis. 2025 Dec 8. [Abstract]
- Cell Death Dis. 2025 Jun 17;16(1):452. [Abstract]
- Cell Death Dis. 2023 Jan 9;14(1):11. [Abstract]
- Cell Death Dis. 2021 Feb 1;12(2):139. [Abstract]
- Cell Death Dis. 2021 Jan 25;12(1):121. [Abstract]
- Cell Death Dis. 2019 Feb 11;10(2):118. [Abstract]
- Cancer Lett. 2022 Mar 31:529:1-10. [Abstract]
- Cell Commun Signal. 2025 Jul 1;23(1):306. [Abstract]
- Phytomedicine. 2024 Nov:134:155988. [Abstract]
- Chin Herb Med. 2024 May 18;17(1):94-107. [Abstract]
- Arch Toxicol. 2024 Jan;98(1):207-221. [Abstract]
- Acta Pharmacol Sin. 2021 Jan;42(1):68-76. [Abstract]
- Sci China Life Sci. 2024 Feb;67(2):360-378. [Abstract]
- Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2303698120. [Abstract]
- Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23869-23878. [Abstract]
- Apoptosis. 2016 Feb;21(2):130-42. [Abstract]
- Int J Biol Macromol. 2024 Oct;278(Pt 4):135015. [Abstract]
- Br J Dermatol. 2024 Aug 14;191(3):385-396. [Abstract]
- ACS Appl Mater Interfaces. 2026 Jun 24;18(24):33542-33558. [Abstract]
- Am J Chin Med. 2022;50(8):2185-2197. [Abstract]
- Cell Rep. 2023 Apr 18;42(5):112414. [Abstract]
- Cell Rep. 2021 Jun 15;35(11):109265. [Abstract]
- Cell Rep. 2020 Nov 10;33(6):108369. [Abstract]
- Transl Psychiatry. 2024 Jan 8;14(1):13. [Abstract]
- Chin Med. 2022 Sep 29;17(1):115. [Abstract]
- Int J Oncol. 2022 Oct;61(4):119. [Abstract]
- Anal Chem. 2017 Sep 19;89(18):9788-9796. [Abstract]
- Cancer Cell Int. 2025 Nov 28;25(1):426. [Abstract]
- Redox Rep. 2025 Dec;30(1):2588086. [Abstract]
- Virulence. 2026 Dec;17(1):2658909. [Abstract]
- Virulence. 2026 Dec;17(1):2670939. [Abstract]
- Virulence. 2025 Dec;16(1):2496436. [Abstract]
- Ecotoxicol Environ Saf. 2025 Apr 15:295:118139. [Abstract]
- Cell Mol Life Sci. 2025 Nov 19;82(1):408. [Abstract]
- Biochem Pharmacol. 2025 Jul 16:241:117178. [Abstract]
- Biochem Pharmacol. 2025 Feb:232:116695. [Abstract]
- Cell Mol Life Sci. 2024 Aug 19;81(1):355. [Abstract]
- Cell Mol Life Sci. 2018 Mar;75(6):1117-1132. [Abstract]
- Food Biosci. 2024 Dec.
- Biosensors (Basel). 2023 Oct 23;13(10):946. [Abstract]
- EMBO Rep. 2024 Oct;25(10):4337-4357. [Abstract]
- Foods. 2022 Jan 17;11(2):240. [Abstract]
- Esophagus. 2026 Mar 19. [Abstract]
- Cancer Biol Ther. 2025 Dec;26(1):2459426. [Abstract]
- Int J Mol Sci. 2026 Apr 2;27(7):3232. [Abstract]
- Int J Mol Sci. 2025 Oct 24;26(21):10347. [Abstract]
- Int Immunopharmacol. 2024 May 30:133:112041. [Abstract]
- mBio. 2026 Apr 8;17(4):e0008126. [Abstract]
- Inflammation. 2025 Dec 20;49(1):12. [Abstract]
- Chem Biol Interact. 2026 Mar 6:431:112011. [Abstract]
- Chem Biol Interact. 2025 Oct 22:420:111693. [Abstract]
- J Nutr Biochem. 2024 Jan:123:109482. [Abstract]
- Toxicology. 2024 Jan:501:153710. [Abstract]
- Molecules. 2023 Jan 30;28(3):1312. [Abstract]
- J Physiol Biochem. 2022 Feb;78(1):125-137. [Abstract]
- Molecules. 2018 May 4;23(5):1083. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2026 Apr 15;1872(6):168261. [Abstract]
- Mol Ther Methods Clin Dev. 2025 Jul 28;33(3):101542. [Abstract]
- Mol Med Rep. 2020 Oct;22(4):2791-2800. [Abstract]
- Mol Med Rep. 2017 Aug;16(2):1093-1100. [Abstract]
- PLoS Pathog. 2026 Feb 25;22(2):e1013874. [Abstract]
- Sci Rep. 2025 Jul 26;15(1):27294. [Abstract]
- Sci Rep. 2024 Mar 30;14(1):7548. [Abstract]
- Cancers (Basel). 2023 Apr 23;15(9):2427. [Abstract]
- Cancers (Basel). 2022 Dec 15;14(24):6206. [Abstract]
- Cancers (Basel). 2022 Nov 9;14(22):5505. [Abstract]
- Cell Signal. 2026 Jun:142:112454. [Abstract]
- Virol Sin. 2026 May 29:S1995-820X(26)00084-2. [Abstract]
- J Cell Mol Med. 2020 Jul;24(14):8151-8165. [Abstract]
- J Cell Mol Med. 2019 Apr;23(4):2489-2504. [Abstract]
- Oncol Rep. 2017 Aug;38(2):1233-1239. [Abstract]
- J Virol. 2022 Jul 13;96(13):e0016722. [Abstract]
- Eur J Immunol. 2020 Jun;50(6):795-808. [Abstract]
- Viruses. 2024 Oct 30;16(11):1695. [Abstract]
- Mol Pain. 2019 Jan-Dec:15:1744806919876150. [Abstract]
- Mol Immunol. 2025 Jun 5:184:22-31. [Abstract]
- Mol Immunol. 2024 Jul 1:172:96-104. [Abstract]
- Mol Immunol. 2023 Jan:153:160-169. [Abstract]
- Transpl Int. 2021 May;34(5):930-941. [Abstract]
- Toxicol Appl Pharmacol. 2016 Feb 1:292:56-64. [Abstract]
- Diabetes Metab Syndr Obes. 2025 Jun 10:18:1903-1914. [Abstract]
- Infect Immun. 2025 Aug 12;93(8):e0015825. [Abstract]
- J Cancer Res Clin Oncol. 2024 Oct 2;150(10):442. [Abstract]
- Adv Biol (Weinh). 2023 Jul;7(7):e2200336. [Abstract]
- Food Chem Toxicol. 2022 Dec:170:113499. [Abstract]
- J Steroid Biochem Mol Biol. 2022 Feb:216:106037. [Abstract]
- PLoS One. 2023 Sep 20;18(9):e0290295. [Abstract]
- Vet Microbiol. 2020 Jan:240:108510. [Abstract]
- Toxicol In Vitro. 2024 May 8:98:105840. [Abstract]
- Virology. 2025 Mar:604:110443. [Abstract]
- Cancer Manag Res. 2020 Jun 10:12:4429-4439. [Abstract]
- Curr Protoc. 2024 Jul;4(7):e1112. [Abstract]
- Biochem Biophys Res Commun. 2019 Jun 11;513(4):883-890. [Abstract]
- J Invertebr Pathol. 2021 Jul:183:107625. [Abstract]
- Ann Hematol. 2026 Feb 11;105(3):107. [Abstract]
- Oncol Lett. 2025 Feb 27;29(4):202. [Abstract]
- Oncol Lett. 2020 Jul;20(1):145-154. [Abstract]
- Nat Prod Commun. 2023 Aug 7.
- SSRN. 2025 Oct 15.
- bioRxiv. 2025 March 20.
- bioRxiv. 2025 January 27.
- bioRxiv. 2025 Jan 9:2025.01.08.632057. [Abstract]
- Preprints. 2024 Aug 14.
- SSRN. 2023 Sep 28.
- Research Square Print. 2023 Feb 3.
- Oxid Med Cell Longev. 2022 Jun 8:2022:8585598. [Abstract]
- Research Square Print. 2022 May.
- Oxid Med Cell Longev. 2022 Feb 7;2022:8217663. [Abstract]
- Hong Kong Polytechnic University. 2022 Feb.
- Research Square Preprint. 2020 Sep.
- Elife. 2020 Jun 2:9:e54954. [Abstract]
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All Caspase Isoforms
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Biological Activity
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Caspase-3 18 μM (IC50) |
N27 cells are exposed to MPP+ in the absence or presence of 50 μM Z-DIPD-FMK or 100 μM Z-DEVD-FMK or 50 μM Z-LEHD-FMK and then caspase-9 and caspase-3 enzymatic activities are determined by enzymatic assay at 12 and 24 h following exposure, respectively. Exposure to 300 μM MPP+ for 24 h in N27 cells results in an approximately 2.5-fold increase in caspase-3 enzyme activity. MPP+-induced increases in caspase-3 enzyme activity are significantly blocked by 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, and 50 μM Z-LEHD-FMK[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 210344-95-9
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Appearance Solid
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Molecular Weight 668.66
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Formula C30H41FN4O12
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Color White to off-white
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SMILES
O=C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)[C@H](CCC(OC)=O)NC([C@H](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (138)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Signal Transduct Target Ther
2024 Feb 28;9(1):43. PMID: 38413575 -
Cell
Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death. [Abstract]2024 Feb 1;187(3):624-641.e23. PMID: 38211590 -
Immunity
A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control. [Abstract]2024 Dec 10;57(12):2737-2754.e12. PMID: 39571575 -
Blood
Plasmin modulates neutrophilic inflammation and alveolar macrophage function, protecting mice from pneumococcal pneumonia. [Abstract]2026 Jan 20:blood.2025028733. PMID: 41557892 -
Cell Mol Immunol
2021 Jan;18(1):219-229. PMID: 31900458
Z-DEVD-FMK purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2021 Jan;18(1):219-229. [Abstract]
TECs were stimulated with 100 μM cisplatin with or without a 50 μM concentration of the caspase 3 inhibitor Z-DEVD-FMK (24 h).
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Autophagy
RETREG1/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis. [Abstract]2026 Jun;22(6):1287-1305. PMID: 41787734 -
Autophagy
Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy. [Abstract]2026 Jan 19:1-16. PMID: 41518198 -
Nat Commun
Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death. [Abstract]2025 Jun 2;16(1):5126. PMID: 40456709 -
Nat Commun
2025 Jan 31;16(1):1233. PMID: 39890804 -
Nat Commun
Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates. [Abstract]2021 Nov 22;12(1):6786. PMID: 34811361 -
J Adv Res
Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway. [Abstract]2025 Jan 25:S2090-1232(25)00059-1. PMID: 39870303 -
Neuron
Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. [Abstract]2024 Oct 23;112(20):3452-3469.e9. PMID: 39153477 -
J Nanobiotechnology
5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia. [Abstract]2025 Mar 28;23(1):252. PMID: 40148810
Z-DEVD-FMK purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 28;23(1):252. [Abstract]
Western blot analysis was performed to assess the expression levels of C-Casp3 and GSDME-N in the DAC + 5-FU@HFn group treated with Z-DEVD-FMK (10 µM; 48 h).
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J Nanobiotechnology
Acute exposure to gold nanoparticles aggravates lipopolysaccharide-induced liver injury by amplifying apoptosis via ROS-mediated macrophage-hepatocyte crosstalk. [Abstract]2022 Jan 20;20(1):37. PMID: 35057820 -
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Biomark Res
SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis. [Abstract]2025 Jan 9;13(1):8. PMID: 39789615 -
Acta Pharm Sin B
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer. [Abstract]2023 Oct;13(10):4253-4272. PMID: 37799380 -
Acta Pharm Sin B
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis. [Abstract]2020 Aug;10(8):1397-1413. PMID: 32963939
Z-DEVD-FMK purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2020 Aug;10(8):1397-1413. [Abstract]
Hepa1-6 cells are treated with miltirone (40 μM) in the absence or presence of Z-DEVD-FMK (20 μM) for 24 h, total cellular extracts are prepared and subjected to Western blotting analyses using antibodies against caspase 3, GSDME, and GADPH.
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Adv Sci (Weinh)
Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis. [Abstract]2026 Apr;13(21):e14863. PMID: 41738282 -
Adv Sci (Weinh)
2026 Mar 18:e74886. PMID: 41848091 -
Adv Sci (Weinh)
2025 Aug 7:e09208. PMID: 40776529 -
Cell Rep Med
5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation. [Abstract]2026 Jan 20;7(1):102537. PMID: 41494533 -
Cell Death Differ
RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production. [Abstract]2026 Apr 4. PMID: 41935203 -
Neuro Oncol
FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells. [Abstract]2023 Oct 3;25(10):1788-1801. PMID: 37083136 -
J Control Release
Reversing immunotherapy resistance in cold tumors by weaponizing pyroptosis with a dual-payload nanotuner. [Abstract]2026 Jun 18:396:115116. PMID: 42314991 -
J Control Release
Low-dose radiation generated ROS-activatable doxorubicin prodrug loaded liposome nanoparticles for triple-negative breast cancer treatment. [Abstract]2026 Feb 27:114750. PMID: 41765334 -
Cell Death Dis
Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium. [Abstract]2025 Dec 8. PMID: 41360763
Z-DEVD-FMK purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Dec 8. [Abstract]
Wild-type 2 dpf embryos were infected in the yolk sac. From 1 h before ST injection, embryos were treated with 50 μM Z-DEVD-FMK and/or the necroptosis inhibitor (necrostatin-2) or DMSO.
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Cell Death Dis
Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. [Abstract]2025 Jun 17;16(1):452. PMID: 40523886 -
Cell Death Dis
The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest. [Abstract]2023 Jan 9;14(1):11. PMID: 36624090 -
Cell Death Dis
Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation. [Abstract]2021 Feb 1;12(2):139. PMID: 33542198 -
Cell Death Dis
Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1. [Abstract]2021 Jan 25;12(1):121. PMID: 33495462 -
Cell Death Dis
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. [Abstract]2019 Feb 11;10(2):118. PMID: 30742128 -
Cancer Lett
Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E. [Abstract]2022 Mar 31:529:1-10. PMID: 34979164 -
Cell Commun Signal
Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1/FADD/caspase-8 complex formation during mitotic arrest in ovarian cancer. [Abstract]2025 Jul 1;23(1):306. PMID: 40597187 -
Phytomedicine
miRNA omics reveal neferine induces apoptosis through Ca2+mediated endoplasmic reticulum stress pathway in human endometrial cancer. [Abstract]2024 Nov:134:155988. PMID: 39226708 -
Chin Herb Med
Paris saponin VII induces Caspase-3/GSDME-dependent pyroptosis in pancreatic ductal adenocarcinoma cells by activating ROS/Bax signaling. [Abstract]2024 May 18;17(1):94-107. PMID: 39949804 -
Arch Toxicol
Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling. [Abstract]2024 Jan;98(1):207-221. PMID: 37955688 -
Acta Pharmacol Sin
Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure. [Abstract]2021 Jan;42(1):68-76. PMID: 32457417 -
Sci China Life Sci
Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure. [Abstract]2024 Feb;67(2):360-378. PMID: 37815699 -
Proc Natl Acad Sci U S A
2023 May 23;120(21):e2303698120. PMID: 37186864 -
Proc Natl Acad Sci U S A
Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target. [Abstract]2020 Sep 22;117(38):23869-23878. PMID: 32907937 -
Apoptosis
Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. [Abstract]2016 Feb;21(2):130-42. PMID: 26531131
Z-DEVD-FMK purchased from MedChemExpress. Usage Cited in: Apoptosis. 2016 Feb;21(2):130-42. [Abstract]
(a) CPT-11 induces cell cycle arrest and apoptosis in RAW 264.7macrophages. a.Western blot analysis of cleaved caspase-3 and PARP levels. (b) CPT-11 induced cell cycle arrest and apoptosis in mouse peritoneal macrophages. Western blot analysis of cleaved caspase-3 and PARP levels in peritoneal macrophages isolated from vehicleand CPT-11-administered mice. (c) Caspase-3 inhibitor z-DEVD-fmk (ZD) attenuates CPT-11-induced loss of GATA6+ peritoneal macrophages in mice. Western blot analy
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Int J Biol Macromol
IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus). [Abstract]2024 Oct;278(Pt 4):135015. PMID: 39181350 -
Br J Dermatol
GSDME-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation. [Abstract]2024 Aug 14;191(3):385-396. PMID: 38655652 -
ACS Appl Mater Interfaces
Nanoparticle-Based Mitochondrial Disruptor Drives Tumor-Selective Pyroptosis for Effective Colorectal Cancer Immunotherapy. [Abstract]2026 Jun 24;18(24):33542-33558. PMID: 42273718 -
Am J Chin Med
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-κ B Signaling Pathway. [Abstract]2022;50(8):2185-2197. PMID: 36222121 -
Cell Rep
2023 Apr 18;42(5):112414. PMID: 37074912 -
Cell Rep
Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn's disease by promoting intestinal inflammation. [Abstract]2021 Jun 15;35(11):109265. PMID: 34133932 -
Cell Rep
Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. [Abstract]2020 Nov 10;33(6):108369. PMID: 33176141 -
Transl Psychiatry
Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients. [Abstract]2024 Jan 8;14(1):13. PMID: 38191558 -
Chin Med
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. [Abstract]2022 Sep 29;17(1):115. PMID: 36175965 -
Int J Oncol
Liproxstatin‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells. [Abstract]2022 Oct;61(4):119. PMID: 36004469 -
Anal Chem
Determination of Caspase-3 Activity and Its Inhibition Constant by Combination of Fluorescence Correlation Spectroscopy with a Microwell Chip. [Abstract]2017 Sep 19;89(18):9788-9796. PMID: 28806521 -
Cancer Cell Int
Natural compound triptolide induces caspase-3/GSDME-mediated pyroptosis by promoting ROS accumulation in small cell lung cancer. [Abstract]2025 Nov 28;25(1):426. PMID: 41316249 -
Redox Rep
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress. [Abstract]2025 Dec;30(1):2588086. PMID: 41292488 -
Virulence
Synergetic attenuated inflammatory response and increased apoptosis confer high pathogenicity of Acinetobacter baumannii. [Abstract]2026 Dec;17(1):2658909. PMID: 41995040 -
Virulence
Integrated transcriptomic and proteomic analysis reveals inflammatory activation and blood-brain barrier disruption during meningitis-associated extraintestinal pathogenic Escherichia coli infection. [Abstract]2026 Dec;17(1):2670939. PMID: 42115138 -
Virulence
Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms. [Abstract]2025 Dec;16(1):2496436. PMID: 40310883 -
Ecotoxicol Environ Saf
Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells. [Abstract]2025 Apr 15:295:118139. PMID: 40185034 -
Cell Mol Life Sci
2025 Nov 19;82(1):408. PMID: 41258568 -
Biochem Pharmacol
2025 Jul 16:241:117178. PMID: 40680865 -
Biochem Pharmacol
Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells. [Abstract]2025 Feb:232:116695. PMID: 39643123 -
Cell Mol Life Sci
Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination. [Abstract]2024 Aug 19;81(1):355. PMID: 39158695 -
Cell Mol Life Sci
Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. [Abstract]2018 Mar;75(6):1117-1132. PMID: 29071384 -
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Biosensors (Basel)
Intensity Interrogation-Based High-Sensitivity Surface Plasmon Resonance Imaging Biosensor for Apoptosis Detection in Cancer. [Abstract]2023 Oct 23;13(10):946. PMID: 37887139 -
EMBO Rep
2024 Oct;25(10):4337-4357. PMID: 39242776 -
Foods
Protective Effect of Ganoderma atrum Polysaccharide on Acrolein-Induced Apoptosis and Autophagic Flux in IEC-6 Cells. [Abstract]2022 Jan 17;11(2):240. PMID: 35053972 -
Esophagus
PCBP2 mediates MTUS1 degradation through 3'-UTR binding to restrict pyroptosis and augment malignant progression in esophageal squamous cell carcinoma. [Abstract]2026 Mar 19. PMID: 41851529 -
Cancer Biol Ther
Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML. [Abstract]2025 Dec;26(1):2459426. PMID: 39878157 -
Int J Mol Sci
2026 Apr 2;27(7):3232. PMID: 41977413 -
Int J Mol Sci
Xanthohumol Triggers Pyroptotic in Prostate Cancer Cells via the Caspase-3/GSDME Signaling Pathway. [Abstract]2025 Oct 24;26(21):10347. PMID: 41226386 -
Int Immunopharmacol
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Mol Ther Methods Clin Dev
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PLoS Pathog
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Sci Rep
2025 Jul 26;15(1):27294. PMID: 40715275 -
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Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis. [Abstract]2022 Dec 15;14(24):6206. PMID: 36551691 -
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Gambogic Acid Induces Pyroptosis of Colorectal Cancer Cells through the GSDME-Dependent Pathway and Elicits an Antitumor Immune Response. [Abstract]2022 Nov 9;14(22):5505. PMID: 36428598 -
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Virol Sin
EV-A71 induces GSDME-dependent T-cell pyroptosis: A novel mechanism and MeCbl therapeutic potential. [Abstract]2026 May 29:S1995-820X(26)00084-2. PMID: 42217583 -
J Cell Mol Med
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J Virol
Nonstructural Protein NSs Activates Inflammasome and Pyroptosis through Interaction with NLRP3 in Human Microglial Cells Infected with Severe Fever with Thrombocytopenia Syndrome Bandavirus. [Abstract]2022 Jul 13;96(13):e0016722. PMID: 35695505 -
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bioRxiv
SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway. [Abstract]2025 Jan 9:2025.01.08.632057. PMID: 39829911 -
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Oxid Med Cell Longev
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Oxid Med Cell Longev
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Elife
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Solvent & Solubility
DMSO : ≥ 50 mg/mL (74.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (1.50 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
N27 cells and primary mesencephalic neurons are exposed to either 10-100 μM 6-OHDA or 10-300 μM MPP+ in the presence or absence of 0.1-50 μM Z-DIPD-FMK or 0.1-100 μM Z-DEVD-FMK or 50 μM Z-IETD-FMK or Z-LEHD-FMK for the duration of the experiment. N27 cells are incubated with 100 μM 6-OHDA for 24 h or 300 μM MPP+ for 36 h in the presence or absence of 50 μM Z-DEVD-FMK and cell death is determined by MTT assay, which is widely used to assess cell viability. After treatment, the cells are incubated in serum-free medium containing 0.25 mg/mL MTT for 3 h at 37°C. Formation of formazan from tetrazolium is measured at 570 nm with a reference wavelength at 630 nm using a SpectraMax microplate reader[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice[2]
Male C57Bl/6 mice (20-25 g) are used. For treatment with Z-DEVD-fmk or vehicle after CCI, mice are placed in a stereotaxic apparatus, and the CCI wound is reopened for intracerebroventricular injection. Either Z-DEVD-FMK (160 ng in 2 μL DMSO), or DMSO vehicle is injected over a 5-minute period.
Rats[3]
Male Sprague Dawley rats (425±25 g) are used. DMSO (5 μL) vehicle or Z-DEVD-FMK (160 ng in 5 μL of DMSO) is administered at a controlled rate of 0.5 μL/min via an infusion pump at 30 min before and at 6 and 24 hr after TBI. At the designated time periods after injury, animals are decapitated under NSC 10816 anesthesia (100 mg/kg, i.p.), and the brains are removed rapidly and dissected. Sham-operated (control) animals received anesthesia and surgery but are not subjected to trauma. Tissue samples are collected 1, 4, 12, 24, and 72 hr after TBI. Samples are frozen on dry ice and kept at −85°C.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (287 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov 15;41(10):1578-89. [Content Brief]
[2]. Knoblach SM, et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32. [Content Brief]
[3]. Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424. [Content Brief]
[4]. Huang MY, et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb;21(2):130-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4955 mL | 7.4776 mL | 14.9553 mL | 37.3882 mL |
| 5 mM | 0.2991 mL | 1.4955 mL | 2.9911 mL | 7.4776 mL | |
| 10 mM | 0.1496 mL | 0.7478 mL | 1.4955 mL | 3.7388 mL | |
| 15 mM | 0.0997 mL | 0.4985 mL | 0.9970 mL | 2.4925 mL | |
| 20 mM | 0.0748 mL | 0.3739 mL | 0.7478 mL | 1.8694 mL | |
| 25 mM | 0.0598 mL | 0.2991 mL | 0.5982 mL | 1.4955 mL | |
| 30 mM | 0.0499 mL | 0.2493 mL | 0.4985 mL | 1.2463 mL | |
| 40 mM | 0.0374 mL | 0.1869 mL | 0.3739 mL | 0.9347 mL | |
| 50 mM | 0.0299 mL | 0.1496 mL | 0.2991 mL | 0.7478 mL | |
| 60 mM | 0.0249 mL | 0.1246 mL | 0.2493 mL | 0.6231 mL |
Z-DEVD-FMK Related Classifications
HY-12466 Related Classifications
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