210344-95-9
210344-95-9
Chemical Structure
Z-DEVD-FMK
- CAS No.: 210344-95-9
- Formula:C30H41FN4O12
- Molecular Weight:668.66
IUPAC Name: methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
InChIKey: GBJVAVGBSGRRKN-JYEBCORGSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)[C@H](CCC(OC)=O)NC([C@H](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O
Biological Activity: Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM[1].
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Z-DEVD-FMK | 98.0% | Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM. | ||||||||||||||||||||
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Z-DEVD-FMK (Standard) | ≥98% | Z-DEVD-FMK (Standard) is the analytical standard of Z-DEVD-FMK (HY-12466). This product is intended for research and analytical applications. Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM. | ||||||||||||||||||||
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Z-IETD-FMK | 98.0% | Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor. | ||||||||||||||||||||
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Z-AEVD-FMK | 95.0% | Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells. | ||||||||||||||||||||
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Z-LEVD-FMK | 98.0% | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells. | ||||||||||||||||||||
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Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK | Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK is an inhibitor for caspase-3, and inhibits Dihydroartemisinin (HY-N0176) and Dictamnine (HY-N0849) co-induced apoptosis. | |||||||||||||||||||||
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Z-LE(OMe)TD(OMe)-FMK | Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis. | |||||||||||||||||||||
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Z-VEID-FMK | 95.0% | Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis. | ||||||||||||||||||||
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Z-VDVAD-FMK | 98.90% | Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis. | ||||||||||||||||||||
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Z-VDVA-(DL-Asp)-FMK | Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2. | |||||||||||||||||||||
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Z-LEED-FMK | Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages. | |||||||||||||||||||||
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Z-DEVD-CMK | 98.99% | Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro. | ||||||||||||||||||||
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