Z-LEVD-FMK
Based on 6 publication(s) in Google Scholar
Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1135688-25-3
- Formula: C31H45FN4O10
- Molecular Weight:652.71
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Endoplasmic Reticulum Stress Compound Library
HY-L054
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Pyroptosis Compound Library
HY-L059
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Protease Inhibitor Library
HY-L147
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Z-LEVD-FMK
MoreAll Caspase Isoforms
More
Biological Activity
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Caspase-4 |
Z-LEVD-FMK (2 ng/mL, 30 min) blocks IL-1β-induced IL-8 production in hRPE cells[1].
Z-LEVD-FMK (2 μM) inhibits caspase-3 activity in hRPE cells[1].
Z-LEVD-FMK (20 μM, 96 h) completely blocks E2-induced PARP cleavage in 5C cells[2].
Z-LEVD-FMK (20 μM, 96 h) reverses E2-inhibited growth and prevents morphologic alterations associated with apoptosis in 5C cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hRPE cells (treated with IL-1β of 2 ng/mL for additional 24 h)
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Concentration:2 ng/mL
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Incubation Time:30 min
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Result:Inhibited IL-1β-induced IL-8 production.
Chemical Information
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CAS No. 1135688-25-3
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Appearance Solid
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Molecular Weight 652.71
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Formula C31H45FN4O10
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Color White to off-white
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SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(N[C@@H](CCC(OC)=O)C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8112):1362-1374. PMID: 42020739 -
Cell
2025 May 29;188(11):3013-3029.e19. PMID: 40252640 -
Nat Commun
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18. [Abstract]2025 Jul 2;16(1):6074. PMID: 40603850 -
Cell Death Discov
2024 Mar 8;10(1):122. PMID: 38458999 -
Microbiol Res
Caspase-4/11-mediated non-canonical pyroptosis disrupts blood-brain barrier integrity via VEGFA/VEGFR2 signaling in Escherichia coli meningitis. [Abstract]2026 Aug:309:128531. PMID: 42034039 -
Solvent & Solubility
DMSO : 125 mg/mL (191.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Bian ZM, et al. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):6006-14. [Content Brief]
[2]. Ariazi EA, et al. Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18879-86. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5321 mL | 7.6604 mL | 15.3207 mL | 38.3018 mL |
| 5 mM | 0.3064 mL | 1.5321 mL | 3.0641 mL | 7.6604 mL | |
| 10 mM | 0.1532 mL | 0.7660 mL | 1.5321 mL | 3.8302 mL | |
| 15 mM | 0.1021 mL | 0.5107 mL | 1.0214 mL | 2.5535 mL | |
| 20 mM | 0.0766 mL | 0.3830 mL | 0.7660 mL | 1.9151 mL | |
| 25 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.5321 mL | |
| 30 mM | 0.0511 mL | 0.2553 mL | 0.5107 mL | 1.2767 mL | |
| 40 mM | 0.0383 mL | 0.1915 mL | 0.3830 mL | 0.9575 mL | |
| 50 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7660 mL | |
| 60 mM | 0.0255 mL | 0.1277 mL | 0.2553 mL | 0.6384 mL | |
| 80 mM | 0.0192 mL | 0.0958 mL | 0.1915 mL | 0.4788 mL | |
| 100 mM | 0.0153 mL | 0.0766 mL | 0.1532 mL | 0.3830 mL |
Z-LEVD-FMK Related Classifications
HY-128707 Related Classifications
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