2. Apoptosis
  3. Caspase
  4. Z-VDVAD-FMK

Z-VDVAD-FMK  (Synonyms: Z-VD(OMe)VAD(OMe)-FMK)

Cat. No.: HY-P1008 Purity: ≥98.0%
COA Handling Instructions

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Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-VDVAD-FMK Chemical Structure

Z-VDVAD-FMK Chemical Structure

CAS No. : 210344-92-6

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1 mg USD 120 In-stock
5 mg USD 300 In-stock
10 mg USD 495 In-stock
25 mg USD 895 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Z-VDVAD-FMK:

Z-VDVAD-FMK Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].

IC50 & Target[1]

Caspase-2

 

In Vitro

Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death[1].
Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells[2]. 
Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z-VDVAD-FMK Related Antibodies

Cell Viability Assay[1]

Cell Line: The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152)
Concentration: 100 μM
Incubation Time: 22 hours
Result: Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.
Molecular Weight

695.73

Formula

C32H46FN5O11
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

{Cbz}-V{Asp(OMe)}-VA-{Asp(OMe)}-CH2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (359.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4373 mL 7.1867 mL 14.3734 mL
5 mM 0.2875 mL 1.4373 mL 2.8747 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (290 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4373 mL 7.1867 mL 14.3734 mL 35.9335 mL
5 mM 0.2875 mL 1.4373 mL 2.8747 mL 7.1867 mL
10 mM 0.1437 mL 0.7187 mL 1.4373 mL 3.5933 mL
15 mM 0.0958 mL 0.4791 mL 0.9582 mL 2.3956 mL
20 mM 0.0719 mL 0.3593 mL 0.7187 mL 1.7967 mL
25 mM 0.0575 mL 0.2875 mL 0.5749 mL 1.4373 mL
30 mM 0.0479 mL 0.2396 mL 0.4791 mL 1.1978 mL
40 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.8983 mL
50 mM 0.0287 mL 0.1437 mL 0.2875 mL 0.7187 mL
60 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5989 mL
80 mM 0.0180 mL 0.0898 mL 0.1797 mL 0.4492 mL
100 mM 0.0144 mL 0.0719 mL 0.1437 mL 0.3593 mL
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Z-VDVAD-FMK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-VDVAD-FMK210344-92-6Z-VD(OMe)VAD(OMe)-FMKCaspaseApoptosisOncosisLovastatinMevalonateCaspase-2Caspase-3HeartCardiomyocyteInhibitorinhibitorinhibit

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