1. Apoptosis
  2. Caspase


Cat. No.: HY-P1008
Handling Instructions

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-VDVAD-FMK Chemical Structure

Z-VDVAD-FMK Chemical Structure

CAS No. : 210344-92-6

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Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].

IC50 & Target[1]



In Vitro

Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death[1].
Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells[2]
Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152)
Concentration: 100 μM
Incubation Time: 22 hours
Result: Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.
Molecular Weight




Sequence Shortening



Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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