Z-VDVAD-FMK
Based on 5 publication(s) in Google Scholar
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 210344-92-6
- Formula: C32H46FN5O11
- Molecular Weight:695.73
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Z-VDVAD-FMK
MoreAll Caspase Isoforms
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Biological Activity
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Caspase-2 |
Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death[1].
Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells[2].
Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152)
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Concentration:100 μM
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Incubation Time:22 hours
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Result:Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.
Chemical Information
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CAS No. 210344-92-6
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Appearance Solid
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Molecular Weight 695.73
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Formula C32H46FN5O11
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Color White to off-white
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Synonyms
Z-VD(OMe)VAD(OMe)-FMK
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Sequence Shortening
{Cbz}-V{Asp(OMe)}-VA-{Asp(OMe)}-CH2F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Cell
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. [Abstract]2025 Mar 20;188(6):1623-1641.e26. PMID: 39938514 -
Int J Biol Macromol
Z-VAD(OMe)-FMK suppresses Seneca Valley Virus replication by targeting the active sites of the 3C protease. [Abstract]2025 May;306(Pt 3):141587. PMID: 40032110 -
Toxicology
Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways. [Abstract]2024 Nov:508:153906. PMID: 39117261 -
Free Radic Res
Dioscin induces ferroptosis to suppress the metastasis of gastric cancer through the SLC7A11/GPX4 axis. [Abstract]2025 May;59(5):426-441. PMID: 40460255
Solvent & Solubility
DMSO : 250 mg/mL (359.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. S Gamen, et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res. 2000 Jul 10;258(1):223-35. [Content Brief]
[2]. Cédric Sapet, et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood. 2006 Sep 15;108(6):1868-76. [Content Brief]
[3]. Simon W Rabkin, et al. Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):346-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4373 mL | 7.1867 mL | 14.3734 mL | 35.9335 mL |
| 5 mM | 0.2875 mL | 1.4373 mL | 2.8747 mL | 7.1867 mL | |
| 10 mM | 0.1437 mL | 0.7187 mL | 1.4373 mL | 3.5933 mL | |
| 15 mM | 0.0958 mL | 0.4791 mL | 0.9582 mL | 2.3956 mL | |
| 20 mM | 0.0719 mL | 0.3593 mL | 0.7187 mL | 1.7967 mL | |
| 25 mM | 0.0575 mL | 0.2875 mL | 0.5749 mL | 1.4373 mL | |
| 30 mM | 0.0479 mL | 0.2396 mL | 0.4791 mL | 1.1978 mL | |
| 40 mM | 0.0359 mL | 0.1797 mL | 0.3593 mL | 0.8983 mL | |
| 50 mM | 0.0287 mL | 0.1437 mL | 0.2875 mL | 0.7187 mL | |
| 60 mM | 0.0240 mL | 0.1198 mL | 0.2396 mL | 0.5989 mL | |
| 80 mM | 0.0180 mL | 0.0898 mL | 0.1797 mL | 0.4492 mL | |
| 100 mM | 0.0144 mL | 0.0719 mL | 0.1437 mL | 0.3593 mL |
Z-VDVAD-FMK Related Classifications
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