210344-92-6
Chemical Structure
Z-VDVAD-FMK
Synonym(s): Z-VD(OMe)VAD(OMe)-FMK
- CAS No.: 210344-92-6
- Formula:C32H46FN5O11
- Molecular Weight:695.73
IUPAC Name: methyl (5S,8S,11S,14S,17S)-17-(2-fluoroacetyl)-5,11-diisopropyl-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate
InChIKey: ANTIWMNLIROOQF-IREHUOSBSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H](CC(OC)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)C(C)C)=O)=O)OCC1=CC=CC=C1
Biological Activity: Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].
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Z-VDVAD-FMK | Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis. | |||||||||||||||||||||
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- [1]. S Gamen, et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res. 2000 Jul 10;258(1):223-35. [Content Brief]
- [2]. Cédric Sapet, et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood. 2006 Sep 15;108(6):1868-76. [Content Brief]
- [3]. Simon W Rabkin, et al. Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors. Toxicol Appl Pharmacol. 2003 Dec 15;193(3):346-55. [Content Brief]
Keywords
