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NEP(1-40) 

Cat. No.: HY-P1242
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NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.

For research use only. We do not sell to patients.

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NEP(1-40) Chemical Structure

NEP(1-40) Chemical Structure

CAS No. : 475221-20-6

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Description

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

In Vivo

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].

Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1].
Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration: IP, 15 min and 19 h post-injury.
Result: Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury
Molecular Weight

2581.95

Formula

C₁₁₈H₁₇₇N₃₅O₂₉S

CAS No.

475221-20-6

Sequence

{Arg}{Ile}{Tyr}{Lys}{Gly}{Val}{Ile}{Gln}{Ala}{Ile}{Gln}{Lys}{Ser}{Asp}{Glu}{Gly}{His}{Pro}{Phe}{Arg}{Ala}{Tyr}{Leu}{Glu}{Ser}{Glu}{Val}{Ala}{Ile}{Ser}{Glu}{Glu}{Leu}{Val}{Gln}{Lys}{Tyr}{Ser}{Asn}{Ser}-NH2

Sequence Shortening

RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

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Keywords:

NEP(1-40)OthersTraumaticbraininjuryTBIMicrogliaNogomyelinoligodendrocytesInhibitorinhibitorinhibit

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NEP(1-40)
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