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  3. NEP(1-40)

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.

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NEP(1-40) Chemical Structure

NEP(1-40) Chemical Structure

CAS No. : 475221-20-6

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Based on 1 publication(s) in Google Scholar

Other Forms of NEP(1-40):

NEP(1-40) Related Antibodies

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1 Publications Citing Use of MCE NEP(1-40)

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Description

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

In Vivo

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1].
Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration: IP, 15 min and 19 h post-injury.
Result: Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury
Molecular Weight

4625.11

Formula

C206H324N56O65
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2
Sequence Shortening

RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 4.17 mg/mL (0.90 mM; ultrasonic and adjust pH to 2 with 1M HCl)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEP(1-40)475221-20-6OthersTraumaticbraininjuryTBIMicrogliaNogomyelinoligodendrocytesInhibitorinhibitorinhibit

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