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  2. NEP(1-40) TFA

NEP(1-40) TFA 

Cat. No.: HY-P1242A
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NEP(1-40) TFA is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.

For research use only. We do not sell to patients.

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NEP(1-40) TFA Chemical Structure

NEP(1-40) TFA Chemical Structure

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Description

NEP(1-40) TFA is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

In Vivo

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].

Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1].
Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration: IP, 15 min and 19 h post-injury.
Result: Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury
Molecular Weight

2695.97

Formula

C₁₂₀H₁₇₈N₃₅F₃O₂₁S

Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2

Sequence Shortening

RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NEP(1-40)OthersTraumaticbraininjuryTBIMicrogliaNogomyelinoligodendrocytesInhibitorinhibitorinhibit

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NEP(1-40) TFA
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