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Cat. No.: HY-P1242A

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NEP(1-40) TFA

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

NEP(1-40) TFA is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.

For research use only. We do not sell to patients.

Formula: C₂₀₆H₃₂₄N₅₆O₆₅.xC₂HF₃O₂
Molecular Weight:4625.11 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NEP(1-40) TFA Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
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Bioz

Biological Activity

Description

NEP(1-40) TFA is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition^[1].

In Vivo

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

74 male Sprague-Dawley rats (328-377 g)^[1].
Dosage:

89 μg/kg (97.5% PBS and 2.5% DMSO).
Administration:

IP, 15 min and 19 h post-injury.
Result:

Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury

Chemical Information

Molecular Weight 4625.11 (free base)
Formula C₂₀₆H₃₂₄N₅₆O₆₅.xC₂HF₃O₂
Sequence

Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2
Sequence Shortening

Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Brain Behav

Baishaoluoshi Decoction Mitigates Post-Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo-A/NgR Signaling Pathway. [Abstract]

2026 Jan;16(1):e71170. PMID: 41474227
Oncol Lett

Nogo-A/NgR signaling regulates stemness in cancer stem-like cells derived from U87MG glioblastoma cells. [Abstract]

2022 May 27;24(1):230. PMID: 35720478

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jenna M Ziebell, et al. Nogo Presence Is Inversely Associated With Shifts in Cortical Microglial Morphology Following Experimental Diffuse Brain Injury. Neuroscience. 2017 Sep 17;359:209-223. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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NEP(1-40) TFA

2 Cited Publications

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Biological Activity
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Publications (2)
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NEP(1-40) TFA

Publications Citing Use of MedChemExpress (MCE) NEP(1-40) TFA

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

NEP(1-40) TFA Related Classifications

Cat. No.: HY-P1242A