1. Peptides
  2. MOG peptide (35-55)

MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide. MOG peptide (35-55) is specific to expanded CD4+ T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model.

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MOG peptide (35-55) Chemical Structure

MOG peptide (35-55) Chemical Structure

CAS No. : 2022956-48-3

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Based on 1 publication(s) in Google Scholar

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Description

MOG peptide (35-55) is a fragment 35-55 of myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide. MOG peptide (35-55) is specific to expanded CD4+ T cells, and induces experimental autoimmune encephalomyelitis (EAE) in animal model[1][2][3].

In Vitro

The expanded CD4+ T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8+ T cells were non-responsive to myelin peptides or proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MOG peptide (35-55) (3 mg/mL for 0.1 mL; s.c.; single dose) results active induction of experimental autoimmune encephalomyelitis (EAE) in mice[2].
MOG peptide (35-55) (200 μg; s.c.; single dose) induces a increasing concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 129S1/SvImJ, C57BL/6 and C57BL/6 X SJL hybrid[2]
Dosage: 3 mg/mL, 0.1 mL per mice; accompanied with CFA and 4 mg/mL Mycobacterium tuberculosis
Administration: Subcutaneous injection; single dose
Result: Showed the expected signs of experimental autoimmune encephalomyelitis (EAE), which started with tail loss of tonus and continued in an ascending fashion in mice immunized with MOG35-55.
Animal Model: C57BL/6 mice (8-12 weeks)[3]
Dosage: 200 μg
Administration: Subcutaneous injection; single dose; analyzed at pre-onset (day 7 post immunization), onset (day 9-13 post immunization) and peak (day 17-19 post immunization)
Result: Increased eosinophil abundance in the spinal cord increases in the course of EAE.
Molecular Weight

2580.97

Formula

C118H178N36O28S

CAS No.
Appearance

Solid

Color

Off-white to light yellow

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (38.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3875 mL 1.9373 mL 3.8745 mL
5 mM 0.0775 mL 0.3875 mL 0.7749 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.72%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3875 mL 1.9373 mL 3.8745 mL 9.6863 mL
5 mM 0.0775 mL 0.3875 mL 0.7749 mL 1.9373 mL
10 mM 0.0387 mL 0.1937 mL 0.3875 mL 0.9686 mL
15 mM 0.0258 mL 0.1292 mL 0.2583 mL 0.6458 mL
20 mM 0.0194 mL 0.0969 mL 0.1937 mL 0.4843 mL
25 mM 0.0155 mL 0.0775 mL 0.1550 mL 0.3875 mL
30 mM 0.0129 mL 0.0646 mL 0.1292 mL 0.3229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MOG peptide (35-55)
Cat. No.:
HY-P3719
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