MOG(35-55) amide, mouse, rat
Based on 1 publication(s) in Google Scholar
MOG (35-55) amide, mouse, rat the terminal amidation form of the 35-55 fragment of the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide (MOG (35-55) (HY-P1240)). MOG(35-55) amide, mouse, rat can be used for experimental autoimmune encephalomyelitis (EAE) modeling.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2022956-48-3
- Formula: C118H178N36O28S
- Molecular Weight:2580.97
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MOG(35-55) amide, mouse, rat
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Biological Activity
The expanded CD4+ T cells are largely specific for the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide 35-55 (MOG35-55), while clonally expanded CD8+ T cells were non-responsive to myelin peptides or proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MOG(35-55) amide, mouse, rat (200 μg, s.c., two immunizations on day 0 and day 7) is a known encephalitis-inducing epitope in C57BL/6 mice, capable of inducing chronic acute exacerbation encephalitis (EAE), but the severity and latency of the disease exhibit significant variability[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Biozzi ABH (H-2dq1) mice (10 weeks old) were subcutaneously injected with an emulsion mixture of antigen and complete Freund's adjuvant (CFA)[2].
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Dosage:200 μg
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Administration:S.c., two immunizations were administered on day 0 and day 7
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Result:Immunized with NF-L protein (200 μg each), significant spastic symptoms were observed, which could induce a classic EAE model characterized by myelin sheath damage and flaccid paralysis.
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Animal Model:Female 8- to 10-week-old C57BL/6 (H-2b)[3].
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Dosage:200 μg
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Administration:S.c., two immunizations were administered on day 0 and day 7
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Result:The incidence of induced EAE was variable (in one experiment, 5 out of 5 mice developed the disease, with an average maximum clinical score of 3.1 (infected mice only) and a group score of 3.1; in another experiment, 3 out of 5 mice developed the disease, with an average maximum clinical score of 2.8 (infected mice) and a group score of 1.7.)
Chemical Information
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CAS No. 2022956-48-3
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Appearance Solid
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Molecular Weight 2580.97
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Formula C118H178N36O28S
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Color White to light yellow
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Sequence
Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-NH2
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Sequence Shortening
MEVGWYRSPFSRVVHLYRNGK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Scand J Immunol
CBL/Cbl-b mediates Fas degradation to reduce neuronal damage in experimental autoimmune encephalomyelitis. [Abstract]2025 Jan;101(1):e13430. PMID: 39726027
Solvent & Solubility
H2O : ≥ 100 mg/mL (38.75 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Saligrama N, et al. Opposing T cell responses in experimental autoimmune encephalomyelitis. Nature. 2019 Aug;572(7770):481-487. [Content Brief]
[2]. Fabiola Puentes, et al. Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2013 Sep 22:10:118. [Content Brief]
[3]. 2. Delarasse C, et al. Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice. Immunology. 2013 Dec;140(4):456-64. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3875 mL | 1.9373 mL | 3.8745 mL | 9.6863 mL |
| 5 mM | 0.0775 mL | 0.3875 mL | 0.7749 mL | 1.9373 mL | |
| 10 mM | 0.0387 mL | 0.1937 mL | 0.3875 mL | 0.9686 mL | |
| 15 mM | 0.0258 mL | 0.1292 mL | 0.2583 mL | 0.6458 mL | |
| 20 mM | 0.0194 mL | 0.0969 mL | 0.1937 mL | 0.4843 mL | |
| 25 mM | 0.0155 mL | 0.0775 mL | 0.1550 mL | 0.3875 mL | |
| 30 mM | 0.0129 mL | 0.0646 mL | 0.1292 mL | 0.3229 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MOG(35-55) amide, mouse, rat Related Classifications
HY-P3719 Related Classifications
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