1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CCR
  4. CCR2 Isoform

CCR2

 
Cat. No. Product Name Effect Purity
  • HY-15418
    RS 504393
    Antagonist 99.75%
    RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).
  • HY-50674
    INCB3344
    Antagonist 99.73%
    INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
  • HY-13245
    PF-4136309
    Antagonist 99.59%
    PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
  • HY-18611
    RS102895 hydrochloride
    Antagonist 99.87%
    RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
  • HY-13406
    TAK-779
    Antagonist 99.73%
    TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.
  • HY-14882
    Cenicriviroc
    Antagonist 99.01%
    Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
  • HY-15450A
    INCB 3284
    Antagonist 99.30%
    INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM.
  • HY-50669A
    MK-0812 Succinate
    Antagonist 99.94%
    MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.
  • HY-103362
    CCR2 antagonist 4 hydrochloride
    Antagonist 99.88%
    CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b.
  • HY-50081
    CCR2-RA-[R]
    Antagonist 98.41%
    CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.
  • HY-14882A
    Cenicriviroc Mesylate
    Antagonist 99.04%
    Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.
  • HY-109593
    BMS-813160
    Antagonist 99.89%
    BMS-813160 is a potent and selective CCR2/5 dual antagonist.
  • HY-101908
    BMS CCR2 22
    Antagonist 99.87%
    BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).
  • HY-135891
    AZD2423
    Antagonist 98.56%
    AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator.
  • HY-103355
    YM022
    Antagonist ≥99.0%
    YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist.
  • HY-101264
    CCR2 antagonist 3
    Antagonist 98.10%
    CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist.
  • HY-108323
    CCR2 antagonist 4
    Antagonist 99.89%
    CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b.
  • HY-112792
    CCR2 antagonist 1
    Antagonist 98.67%
    CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.
  • HY-117621
    PF-04634817
    Antagonist 98.87%
    PF-0463481 is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM).
  • HY-18611A
    RS102895
    Antagonist
    RS102895 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
Cat. No. Product Name / Synonyms Species Source