1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. CCR2 antagonist 4 hydrochloride

CCR2 antagonist 4 hydrochloride (Synonyms: Teijin compound 1 hydrochloride)

Cat. No.: HY-103362
Handling Instructions

CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.

For research use only. We do not sell to patients.

CCR2 antagonist 4 hydrochloride Chemical Structure

CCR2 antagonist 4 hydrochloride Chemical Structure

CAS No. : 1313730-14-1

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Description

CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM[1].

IC50 & Target[1]

CCR2b

180 nM (IC50)

In Vitro

Ile263 and Thr292 in CCR2 contribute significantly to binding of CCR2 antagonist 4 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride[2].

In Vivo

In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta[3].

Molecular Weight

476.32

Formula

C₂₁H₂₂Cl₂F₃N₃O₂

CAS No.

1313730-14-1

SMILES

O=C(NCC(N[[email protected]]1CN(CC2=CC=C(Cl)C=C2)CC1)=O)C3=CC=CC(C(F)(F)F)=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CCR2 antagonist 4Teijin compound 1Teijin compound1Teijin compound-1CCRCC chemokine receptorchemokineschronicinflammatoryCCR2bMCP-1chemotaxisInhibitorinhibitorinhibit

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Product name:
CCR2 antagonist 4 hydrochloride
Cat. No.:
HY-103362
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