1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR

SB297006 

Cat. No.: HY-103361 Purity: 99.77%
Handling Instructions

SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

For research use only. We do not sell to patients.

SB297006 Chemical Structure

SB297006 Chemical Structure

CAS No. : 58816-69-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

View All CCR Isoform Specific Products:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SB297006 is a CCR3 antagonist, which significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells.

IC50 & Target

CCR3[1]

In Vitro

SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 μM[1].

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (438.15 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9210 mL 14.6049 mL 29.2099 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL
10 mM 0.2921 mL 1.4605 mL 2.9210 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

References
Cell Assay
[1]

To evaluate CCR3 blocking, neural progenitor cells (NPCs) are incubated with the CCR3 antagonist SB297006 (100 μM) for 30 minutes and then stimulated with CCL11 (2 μg/mL). After 3 days of culture, NPCs are subjected to CCK-8 assays[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

342.35

Formula

C₁₈H₁₈N₂O₅

CAS No.

58816-69-6

SMILES

O=C(OCC)[[email protected]](CC1=CC=C([N+]([O-])=O)C=C1)NC(C2=CC=CC=C2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SB297006
Cat. No.:
HY-103361
Quantity:

SB297006

Cat. No.: HY-103361