CCR Inhibitors

CCR1

CCR2

CCR3

CCR4

CCR5

CCR6

CCR7

CCR8

CCR9

CCR Inhibitors, Agonists, Antagonists, Activators, Chemicals, Degraders & Ligands

Product Name	CCR1	CCR2	CCR3	CCR4	CCR5	CCR6	CCR7	CCR8	CCR9	Purity
Maraviroc					MIP-1α-CCR5, IC₅₀: 3.3 nM (in HEK-293 cell membrane) MIP-1β-CCR5, IC₅₀: 7.2 nM (in HEK-293 cell membrane) RANTES-CCR5, IC₅₀: 5.2 nM (in HEK-293 cell membrane)					99.98%
RS 504393		CCR2, IC₅₀: 89 nM								99.72%
BX471	MIP-1α-CCR1, Ki: 1 nM RANTES-CCR1, Ki: 2.8 nM MCP-3-CCR1, Ki: 5.5 nM									99.98%
S-531011 (FUT8-KO)								CCR8
INCB3344		hCCR2, IC₅₀: 5.1 nM mCCR2, IC₅₀: 9.5 nM								99.08%
TAK-779		MCP-1-CCR2b, IC₅₀: 27 nM (in CHO/CCR5 cells)			MIP-1α-CCR5, IC₅₀: 1 nM (in CHO/CCR5 cells) MIP-1β-CCR5, IC₅₀: 1 nM (in CHO/CCR5 cells) RANTES-CCR5, IC₅₀: 1.4 nM (in CHO/CCR5 cells)					99.89%
CCR6 antagonist 1						CCR6				99.30%
Abaucin	CCR1, IC₅₀: 17800 nM	CCR2, IC₅₀: 360 nM								99.59%
Cenicriviroc		CCR2, IC₅₀: 5.9 nM			CCR5, IC₅₀: 0.29 nM					99.51%
PF-4136309		Human CCR2, IC₅₀: 5.2 nM Mouse CCR2, IC₅₀: 13 nM Rat CCR2, IC₅₀: 17 nM								99.86%
BX471 hydrochloride	MIP-1α-CCR1, Ki: 1 nM RANTES-CCR1, Ki: 2.8 nM MCP-3-CCR1, Ki: 5.5 nM									99.94%
Abaucin hydrochloride	CCR1, IC₅₀: 17800 nM	CCR2, IC₅₀: 360 nM								99.90%
SB-328437			CCR3, IC₅₀: 4.5 nM CCR3, IC₅₀: 4.5 nM							99.58%
CCR7 Ligand 1							Human CCR7, Kd: 3 nM			99.19%
CCR6 inhibitor 1						Moneky CCR6, IC₅₀: 0.45 nM Human CCR6, IC₅₀: 6 nM	Human CCR7, IC₅₀: 9400 nM			99.60%
AZD2098				CCR4						99.91%
DAPTA					gp120_BaL/sCD4-CCR5, IC₅₀: 55 pM (in Cf2Th/synR5 cells) gp120CM_CM235/sCD4-CCR5, IC₅₀: 0.32 nM (in Cf2Th/synR5 cells)					98.87%
Cosalane							CCR7, IC₅₀: 2.43 μM			99.78%
C-021 dihydrochloride				CCR4						99.92%
Zelnecirnon				CCR4						99.71%
J-113863	CCR1, IC₅₀: 0.9 nM (Human CCR1) CCR1, IC₅₀: 5.8 nM (Mouse CCR1)		CCR3, IC₅₀: 0.58 nM (Human CCR3) CCR3, IC₅₀: 460 nM (Mouse CCR3)							≥99.0%
Vercirnon									CCR9, IC₅₀: 10 nM	98.01%
PF-07054894						CCR6				99.15%
AZ084								CCR8, Ki: 0.9 nM		99.65%
C-021				CCR4						99.95%
Mogamulizumab				CCR4
CCR2 antagonist 4		CCR2b, IC₅₀: 180 nM								99.89%
R243								CCR8		98.09%
BMS-813160		CCR2, IC₅₀: 6.2 nM			CCR5, IC₅₀: 3.6 nM					99.93%
Tivumecirnon				CCR4						99.48%
GW 766994			CCR3, pKi: 7.86							98.73%
CCR2-RA-[R]		CCR2, IC₅₀: 103 nM								99.21%
ML604086								CCR8		99.78%
Cenicriviroc Mesylate		CCR2, IC₅₀: 5.9 nM			CCR5, IC₅₀: 0.29 nM					99.94%
INCB 3284		MCP-1-hCCR2, IC₅₀: 3.7 nM								99.30%
SB297006			CCR3							99.86%
Plozalizumab		CCR2								99.53%
BMS CCR2 22		CCR2, IC₅₀: 5.1 nM								99.27%
Medrysone		CCR2								99.79%
Denikitug								CCR8, Kd: 16.8 pM		99.00%
CCR2 antagonist 4 hydrochloride		CCR2b, IC₅₀: 180 nM								99.91%
LMD-009								CCR8, EC₅₀: 11-87 nM		99.35%
CCR4 antagonist 4				CCR4, IC₅₀: 0.02 μM						98.92%
Vercirnon sodium									CCR9, IC₅₀: 10 nM	98.04%
YM022	CCR1, Ki: 63 nM	CCR2, Ki: 68 pM								99.87%
Ilacirnon		hCCR2, Kd: 2.3 nM (in monocytes) CCR2, IC₅₀: 3 nM (in THP-1 cells)			CCR5, IC₅₀: 7 μM (in Activated T lymphocytes)					98.05%
GSK2239633A				[¹²⁵I]-TARC-CCR4, pIC₅₀: 7.96						99.81%
CKLF1-C27				CCR4						98.02%
MK-0812 Succinate		CCR2								99.94%
AZD-4818	CCR1									99.10%
IDOR-1117-2520						CCR6				99.94%
MK-0812		CCR2								99.89%
ZK756326 dihydrochloride								CCR8, IC₅₀: 1.8 μM (in U87 cells)		99.87%
TAK-220					RANTES-CCR5, IC₅₀: 3.5 nM (in CHO cells) MIP-1α-CCR5, IC₅₀: 1.4 nM (in CHO cells)					99.95%
Met-RANTES (human) acetate	CCR1				CCR5					99.39%
AZD2423		CCR2								99.91%
CCX354	CCR1									99.18%
BI 639667	CCR1, IC₅₀: 1.8 nM (in Ca²⁺ flux assay)									98.87%
Vicriviroc maleate					CCR5, Ki: 2.5 nM					99.91%
CKLF1-C19			CCR3	CCL17-CCR4						99.11%
Aplaviroc hydrochloride					CCR5					99.94%
CCR8 antagonist 1								CCR8, Ki: 1.6 nM		99.50%
CCR3 antagonist 1			CCR3							99.90%
ALK4290			CCR3, Ki: 3.2 nM							99.79%
BMS-817399	CCR1, IC₅₀: 1 nM									99.66%
CCR1 antagonist 9	CCR1, IC₅₀: 6.8 nM (in calcium flux assay)									99.65%
Tagmokitug								CCR8, Kd: 502 pM		99.9%
CCR2-IN-1		CCR2
CCR4-351				CCR4						98.95%
PF-04634817 succinate		Rat CCR2, IC₅₀: 20.8 nM			CCR5, IC₅₀: 470 nM					99.50%
Nifeviroc					CCR5					99.39%
CCR2 antagonist 1		CCR2, Ki: 2.4 nM								98.00%
CCR2 antagonist 3		CCR2								99.91%
JNJ-41443532		hCCR2, IC₅₀: 37 nM mCCR2, Ki: 9.6 μM								99.65%
JNJ-27141491		hCCR2
S-531011								CCR8		98.38%
CCR4-351 hydrochloride				CCR4						98.14%
PF-04634817		Rat CCR2, IC₅₀: 20.8 nM			CCR5, IC₅₀: 470 nM					98.87%
AZD-5672					CCR5, IC₅₀: 0.32 nM
Met-RANTES (human)	CCR1				CCR5
INCB3344 R-isomer		CCR2								98.01%
Calamenene							CCR7
Aplaviroc					CCR5
(S)-IDOR-1117-2520						CCR6				99.47%
CCR4 antagonist 3				[¹²⁵I]-TARC-CCR4, IC₅₀: 1.7 μM						99.94%
DOTA-ECL1i		CCR2								98.06%
Lanerkitug								CCR8
INCB 3284 dimesylate		MCP-1-hCCR2, IC₅₀: 3.7 nM								≥98.0%
YJC-10592		CCR2
CCR5 antagonist 3					CCR5, IC₅₀: 15.90 nM
CCR1 antagonist 10	CCR1
LMD-902								CCR8, EC₅₀: 15 nM
Ancriviroc					CCR5, IC₅₀: 13 nM
JNJ-17166864		CCR2
INCB9471					CCR5
Fuscin					CCR5
YM-344484			CCR3
LUF8100		CCR2, pKi: 5.23			CCR5, pKi: 4.97					98.64%
Viscumneoside V		CCR2								98.24%
CP-481715	CCR1, Kd: 9.2 nM
GSK-2239633				CCR4
Enzelkitug (FUT8-KO)								CCR8
AZD3778			CCR3, IC₅₀: 8.1 nM
Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA		CCR2
ECL1i		CCR2
CCR2-RA		CCR2
PNU-177864					CCR5
SB-649701								CCR8, pIC₅₀: 7.7
BMS-570520			CCR3, IC₅₀: 1.9 nM
Anti-CCL2 (Carlumab)-SMCC-DM1		CCR2
CCR5 antagonist 2					CCR5, IC₅₀: 8.34 nM
BMS-741672		CCR2, IC₅₀: 1.1 nM			CCR5, IC₅₀: 780 nM
Lanerkitug (FUT8-KO)								CCR8
Anti-CCL2 (Carlumab)-SPDB-DM4		CCR2
CCR5 antagonist 1					CCR5
CCR9 ligand-Linker Conjugate 1									CCR9
Enzelkitug								CCR8
CXCR2 antagonist 10		CCR2, : 0.48 μM					CCR7, : 2.07 μM
Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38		CCR2
ST45177901				CCR4
RO5234444		Human CCR2, IC₅₀: 22 nM Mouse CCR2, IC₅₀: 161 nM
ZL-1218 (FUT8-KO)								CCR8
YM-344031			CCR3
CKLF1-C27 TFA				CCR4
CCR1 antagonist 12	CCR1, IC₅₀: 3 nM
Maceneolignan H			CCR3
Propagermanium		CCR2
CCR2 ligand-1		CCR2
BMS-639623			CCR3, IC₅₀: 0.3 nM
Anti-CCL2 (Carlumab)-McMMAF		CCR2
PF-4178903		CCR2, IC₅₀: 3 nM			CCR5, IC₅₀: 5.3 nM
LMD-584								CCR8
HGS004					CCR5
CB-0821					CCR5, Ki: 0.04 nM
LUF7996		CCR2, DC₅₀: 2.6 μM
PROTAC CCR9 Degrader 1									CCR9, Ki: 78.0 nM
CCR1 antagonist 13	CCR1
Ophiobolin C					CCR5
CCR6 antagonist 4						CCR6, IC₅₀: 158 nM
CCR2 antagonist 6		CCR2, Kb: 0.215 μM
E913					CCR5
Emapticap pegol scramble negative control		CCR2
CCR8 antagonist 3								CCR8, IC₅₀: 0.062 μM
CP-865569	CCR1
ZL-1218								CCR8
CCR6 antagonist 3						CCR6, IC₅₀: 166 nM

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