887401-92-5
Chemical Structure
INCB 3284
- CAS No.: 887401-92-5
- Formula:C26H31F3N4O4
- Molecular Weight:520.54
IUPAC Name: N-(2-(((R)-1-((1s,4S)-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
InChIKey: NXZNYBUBXWWKCP-OTPAQWSUSA-N
SMILES: O=C(NCC(N[C@H]1CN([C@H]2CC[C@@](C3=CC=C(OC)N=C3)(O)CC2)CC1)=O)C4=CC=CC(C(F)(F)F)=C4
Biological Activity: INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure.
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INCB 3284 | 99.30% | INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure. | ||||||||||||||||||||
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Keywords
