2. Disease Areas
  3. Digestive System Disease
  4. Liver Disease
  5. Liver Failure

Liver Failure

Acute liver failure is a rapidly progressive condition marked by severe hepatocyte loss in individuals without prior liver disease, triggered by diverse factors such as toxins, infections, malignancies, or drugs. Chronic liver failure represents the end stage of progressive chronic liver disease, characterized by extensive fibrosis and impaired liver function, leading to decompensated symptoms. Transient infantile liver failure results from mutations in the TRMU gene on chromosome 22q13, disrupting mitochondrial protein translation and causing mitochondrial dysfunction, manifesting as elevated liver enzymes, jaundice, vomiting, coagulopathy, hyperbilirubinemia, and elevated lactate. The condition typically resolves with supportive care and normal neurodevelopment, though more severe forms involve mitochondrial DNA depletion and resemble transient infantile mitochondrial myopathy.

Liver Failure (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-150097
    Recombinant Human Serum Albumin(rHSA) 99.6%
    Recombinant Human Serum Albumin (rHSA) is a non-glycosylated monomeric plasma protein that acts as a core factor for maintaining plasma colloid osmotic pressure. Recombinant Human Serum Albumin (rHSA) possesses multiple physiological functions including carrier, metabolic regulation, detoxification, antioxidation and enzyme mimicking. Recombinant Human Serum Albumin (rHSA) not only scavenges reactive oxygen and nitrogen species via specific residues and binds a variety of endogenous and exogenous compounds to maintain redox homeostasis, but also serves as a biomarker for multiple diseases such as cancer and inflammation. Recombinant Human Serum Albumin (rHSA) broadly supports the development of implantable materials, surgical adhesives and ligand capture, and can be used for research on critical illnesses including hypovolemia, liver failure, severe sepsis and various types of trauma resuscitation.
    Recombinant Human Serum Albumin(rHSA)
  • HY-111096
    IDN-7314 254750-11-3
    IDN-7314 is a pan-Caspase inhibitor with an IC50 of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury.
    IDN-7314