254750-11-3
Chemical Structure
IDN-7314
- CAS No.: 254750-11-3
- Formula:C22H17F6N3O7
- Molecular Weight:549.38
IUPAC Name: (S)-3-((S)-2-(2-((2,6-difluorophenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
InChIKey: VMPUKWSLCRUGSR-SDBXPKJASA-N
SMILES: O(CC([C@@H](NC([C@@H](NC(C(NC1=C(F)C=CC=C1F)=O)=O)C)=O)CC(O)=O)=O)C2=C(F)C(F)=CC(F)=C2F
Biological Activity: IDN-7314 is a pan-Caspase inhibitor with an IC50 of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury[1][2].
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IDN-7314 | IDN-7314 is a pan-Caspase inhibitor with an IC50 of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury. | |||||||||||||||||||||
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- [1]. Gujral JS, et al. Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats. Toxicol Appl Pharmacol. 2003;190(1):37-46. [Content Brief]
- [2]. Kopec AK, et al. Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo. Toxicol Sci. 2018;162(2):396-405. [Content Brief]
Keywords
