rac-Lenalidomide-13C5
rac-Lenalidomide-13C5 (CC-5013-13C5) is the 13C5-labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8+ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury.
For research use only. We do not sell to patients.
- CAS No.: 1219332-91-8
- Formula: C813C5H13N3O3
- Molecular Weight:264.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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Cereblon |
IKZF1 |
IKZF3 |
Chemical Information
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CAS No. 1219332-91-8
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Unlabeled CAS 191732-72-6
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Molecular Weight 264.22
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Formula C813C5H13N3O3
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SMILES
O=[13C](N1)[13CH2][13CH2][13CH](N2CC3=C(C=CC=C3C2=O)N)[13C]1=O
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Synonyms
CC-5013-13C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Krönke J, et al. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature. 2015 Jul 9;523(7559):183-188. [Content Brief]
[2]. Minnie SA, et al. TIGIT inhibition and lenalidomide synergistically promote antimyeloma immune responses after stem cell transplantation in mice. The Journal of clinical investigation. 2023 Feb 15;133(4):e157907. [Content Brief]
[3]. Wang Y, et al. TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury. Cell Prolif. 2020 Jun;53(6):e12829. [Content Brief]
[4]. Lu G, et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science (New York, N.Y.). 2014 Jan 17;343(6168):305-9. [Content Brief]
[5]. Rozewski DM, et al. Pharmacokinetics and tissue disposition of lenalidomide in mice. The AAPS journal. 2012 Dec;14(4):872-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
rac-Lenalidomide-13C5 Related Classifications
HY-W777286 Related Classifications
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Keywords
- rac-Lenalidomide-13C5
- 1219332-91-8
- CC-5013-13C5
- Isotope-Labeled Compounds
- Molecular Glues
- Ligands for E3 Ligase
- IKZF Family
- Casein Kinase
- Apoptosis
- Pyroptosis
- MDM-2/p53
- TNF Receptor
- KG-1 cells
- IKZF3
- cereblon
- M1 macrophages
- myelodysplastic syndrome
- multiple myeloma
- CK1α
- CD8+ T cell
- THP-1 cells
- IKZF1
- Inhibitor
- inhibitor
- inhibit