DDB1

DNA damage-binding protein 1

DNA Damage Binding Protein-1 (DDB1) is a protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. The ubiquitin–proteasome system is a significant pathway that precisely governs protein stability. Among the Cullin-RING Ligase (CRL) family, a typical CRL4 ligase is composed of a scaffold Cullin (CUL4A or CUL4B) protein, a linker protein-DDB1, a substrate recognition adaptor (DCAF), and a ring protein with intrinsic E3 activity (RBX1 or RBX2).

References:

[1]. Luo D, et al. CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression. Exp Hematol Oncol. 2023 Sep 7;12(1):77. [Content Brief]

DDB1 Related Products (1):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-175890

DDB1 ligand-2
DDB1 ligand-2 is an E3 ligase ligand. DDB1 ligand-2 can be coupled with BRD4 ligand JQ-1 carboxylic acid (HY-78695) via the linker NH2-C5-NH-Boc (HY-W004710) to form PROTAC MM-02-08 (HY-161167).

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