2. PROTAC
  3. PROTAC Linkers
  4. NH2-C5-NH-Boc

NH2-C5-NH-Boc  (Synonyms: PROTAC Linker 23)

Cat. No.: HY-W004710 Purity: 99.88%
COA Handling Instructions

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NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-C5-NH-Boc Chemical Structure

NH2-C5-NH-Boc Chemical Structure

CAS No. : 51644-96-3

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500 mg USD 40 In-stock
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Based on 1 publication(s) in Google Scholar

NH2-C5-NH-Boc Related Antibodies

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Description

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-C5-NH-Boc Related Antibodies
Molecular Weight

202.29

Formula

C10H22N2O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)NCCCCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (494.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9434 mL 24.7170 mL 49.4340 mL
5 mM 0.9887 mL 4.9434 mL 9.8868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

COA (241 KB) HNMR (134 KB) GC (203 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 4.9434 mL 24.7170 mL 49.4340 mL 123.5850 mL
5 mM 0.9887 mL 4.9434 mL 9.8868 mL 24.7170 mL
10 mM 0.4943 mL 2.4717 mL 4.9434 mL 12.3585 mL
15 mM 0.3296 mL 1.6478 mL 3.2956 mL 8.2390 mL
20 mM 0.2472 mL 1.2358 mL 2.4717 mL 6.1792 mL
25 mM 0.1977 mL 0.9887 mL 1.9774 mL 4.9434 mL
30 mM 0.1648 mL 0.8239 mL 1.6478 mL 4.1195 mL
40 mM 0.1236 mL 0.6179 mL 1.2358 mL 3.0896 mL
50 mM 0.0989 mL 0.4943 mL 0.9887 mL 2.4717 mL
60 mM 0.0824 mL 0.4119 mL 0.8239 mL 2.0597 mL
80 mM 0.0618 mL 0.3090 mL 0.6179 mL 1.5448 mL
100 mM 0.0494 mL 0.2472 mL 0.4943 mL 1.2358 mL
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NH2-C5-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-C5-NH-Boc51644-96-3PROTAC Linker 23PROTAC Linker23PROTAC Linker-23PROTAC LinkersInhibitorinhibitorinhibit

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