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Cat. No.: HY-186265

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SD-24

SD-24 is a selective antagonist targeting CCR2 with a K_i of 1 nM, and exhibits significantly reduced binding affinity to CXCR1 and CCR6. SD-24 is applicable for inflammation and immune-related research.

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CAS No.: 1237502-86-1
Formule: C₁₉H₁₂Cl₃NO₅S
Masse moléculaire:472.73

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Please store the product under the recommended conditions in the Certificate of Analysis.

SD-24 Chemical Structure

CAS No.: 1237502-86-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

CCR2

1 nM (Ki)

Voir tous les produits spécifiques à Isoform CCR :

In Vitro

SD-24 (compound 15) (10 μM) shows no significant binding to the IABS of CXCR1_Nluc and CCR6_Nluc in HEK293T cell membranes at a concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1237502-86-1
Masse moléculaire 472.73
Formule C₁₉H₁₂Cl₃NO₅S
SMILES

O=C(O)C1=CC=CC=C1OC2=C(NS(=O)(C3=CC(Cl)=C(Cl)C=C3)=O)C=C(Cl)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Huber ME, et al. Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1. ChemMedChem. 2024 Oct 16;19(20):e202400284. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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SD-24

Voir tous les produits spécifiques à Isoform CCR