CCR6
C-C chemokine receptor type 6 (CCR6, CD196) is a Gαi-coupled chemokine receptor distinguished by having a single ligand, CCL20 (MIP-3α/LARC/Exodus-1), a homeostatic-inflammation dual-purpose chemokine produced by intestinal epithelium, keratinocytes, lymphoid tissue stroma and inflamed tissues. CCR6 expression defines immature dendritic cells of the myeloid lineage (guiding their positioning in epithelial immune surveillance), B cells, and the Th17/TCRγδ/ILC3 axis of adaptive and innate lymphocytes: CCR6+ cells home to CCL20-rich mucosal sites, particularly Peyer's patches, intestinal lamina propria and skin. In the gut, the CCR6-CCL20 pair integrates microbiota-derived signals with lymphoid tissue organogenesis and Th17-driven defense against Citrobacter and fungal pathogens. Pathologically, the axis recruits pathogenic Th17 cells in psoriasis, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis models. CCR6-bearing tumor cells use the same route to metastasize to lymph nodes, and CCR6 antagonism has been explored for autoimmune and metabolic inflammation.
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CCR6 Recombinant Proteins (2)
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Inhibitors & Agonists (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
