CCR6 Protein, Mouse (Cell-Free, His)

The CCR6 Protein acts as a receptor for the C-C type chemokine CCL20, transducing signals by increasing intracellular calcium ion levels upon binding to its major ligand. Notably, CCR6 can also function as a receptor for non-chemokine ligands, such as beta-defensins, including DEFB1, DEFB4, and DEFB4A/B. The interaction between CCR6 and DEFB1 is crucial for regulating sperm motility and bactericidal activity. Additionally, CCR6 plays a pivotal role in chemotaxis, being responsible for the migration of dendritic cells, effector/memory T-cells, and B-cells, particularly at skin and mucosal surfaces under various conditions, including inflammation and pathology such as cancer and autoimmune diseases. CCR6-mediated signals are essential for immune responses in the intestinal mucosa, modulating inflammatory responses to tissue insult and trauma. Moreover, CCR6 is indispensable for recruiting pro-inflammatory IL17-producing helper T-cells (Th17) and regulatory T-cells (Treg) to sites of inflammation, influencing thymocyte precursor migration events, B-cell localization in Peyers-patches, and the efficient secondary recall response of memory B-cells. It also positively regulates sperm motility and chemotaxis through its binding to CCL20.