229005-80-5
Chemical Structure
TAK-779
Synonym(s): Takeda 779
- CAS No.: 229005-80-5
- Formula:C33H39ClN2O2
- Molecular Weight:531.13
IUPAC Name: N,N-dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride
InChIKey: VDALIBWXVQVFGZ-UHFFFAOYSA-N
SMILES: C[N+](C)(CC1=CC=C(NC(C2=CC3=CC(C4=CC=C(C)C=C4)=CC=C3CCC2)=O)C=C1)C5CCOCC5.[Cl-]
Biological Activity: TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TAK-779 | 99.50% | TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells. | ||||||||||||||||||||
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