CXCR3
C-X-C chemokine receptor type 3 (CXCR3, CD183) is a Gαi-coupled receptor central to Th1 immunity, activated by the interferon-inducible ligands CXCL9 (MIG), CXCL10 (IP-10) and CXCL11 (I-TAC), with CXCL11 showing highest affinity for CXCR3A and several ligands engaging the alternatively spliced CXCR3B isoform. CXCR3A is induced on activated T cells by IL-12/IL-18/T-bet-driven Th1 differentiation, marking effector and memory Th1 cells, CD8+ T cells, NK cells and a subset of B cells; ligand engagement promotes chemotaxis to inflamed tissues where IFN-γ from these same cells induces CXCL9/10/11, creating an amplification loop. CXCR3B, expressed on endothelial and epithelial cells, binds angiostatic ligands and inhibits migration and angiogenesis. Clinically, the CXCR3 axis drives T-cell infiltration in allograft rejection, multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease. In cancer, CXCR3+ T-cell recruitment favors tumors with an inflamed phenotype, while CXCL10-mediated CXCR3 signaling paradoxically supports metastasis of CXCR3+ tumor cells to lung, liver, bone and brain.
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CXCR3 Recombinant Proteins (3)
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Inhibitors & Agonists (16)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
