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Art. -Nr.: HY-186116

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LSD1-IN-49

LSD1-IN-49 is an irreversible LSD1/KDM1A inhibitor with an IC₅₀ of 29 nM against hLSD1. LSD1-IN-49 irreversibly inhibits the enzymatic activity of LSD1 by forming an adduct with flavin adenine dinucleotide (FAD) in the binding pocket of LSD1. LSD1-IN-49 is applicable to research related to schizophrenia, autism spectrum disorder and Huntington's disease.

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CAS. Nr.: 1422533-70-7
Formel: C₂₆H₂₆N₂O
Molecular Weight:382.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSD1-IN-49 Chemical Structure

CAS. Nr.: 1422533-70-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

LSD1

29 (hLSD1) nM (IC₅₀)

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen :

In Vitro

LSD1-IN-49 (Compound (±) 1) irreversibly inhibits the activity of recombinant hLSD1 enzyme, with an IC₅₀ of 29 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1422533-70-7
Molecular Weight 382.50
Formel C₂₆H₂₆N₂O
SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC(C=C3)=CC=C3[C@H](C4)[C@@H]4NCC5CC5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Hattori Y, et al. Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain. J Med Chem. 2021;64(7):3780-3793. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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LSD1-IN-49

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

LSD1-IN-49 Related Classifications

HY-186116 Related Classifications