445479-97-0
Chemical Structure
BMS CCR2 22
- CAS No.: 445479-97-0
- Formula:C28H34F3N5O4S
- Molecular Weight:593.66
IUPAC Name: 2-(3-isopropylureido)-N-(2-(((1S,2R)-2-(4-(methylthio)benzamido)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)benzamide
InChIKey: IBPXYDUJQWENPM-XZOQPEGZSA-N
SMILES: O=C(NCC(N[C@@H]1[C@H](NC(C2=CC=C(SC)C=C2)=O)CCCC1)=O)C3=CC(C(F)(F)F)=CC=C3NC(NC(C)C)=O
Biological Activity: BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM)[1][2].
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BMS CCR2 22 | 99.27% | BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM). | ||||||||||||||||||||
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BMS CCR2 22 (Standard) | ≥98% | BMS CCR2 22 (Standard) is the analytical standard of BMS CCR2 22 (HY-101908). This product is intended for research and analytical applications. BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM). | ||||||||||||||||||||
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- [1]. Cherney RJ, et al. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J Med Chem. 2008 Feb 28;51(4):721-4. [Content Brief]
- [2]. Kredel S, et al. High-content analysis of CCR2 antagonists on human primary monocytes. J Biomol Screen. 2011 Aug;16(7):683-93. [Content Brief]
Keywords
