1341224-83-6
1341224-83-6
Chemical Structure
PF-4136309
Synonym(s): INCB8761
- CAS No.: 1341224-83-6
- Formula:C29H31F3N6O3
- Molecular Weight:568.59
IUPAC Name: N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
InChIKey: ZNSVOHSYDRPBGI-LXWOLXCRSA-N
SMILES: O[C@]1(CC[C@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5
Biological Activity: PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PF-4136309 | 99.86% | PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
