1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Psychosine

Psychosine (Synonyms: Galactosylsphingosine)

Cat. No.: HY-136490
Handling Instructions

Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC.

For research use only. We do not sell to patients.

Psychosine Chemical Structure

Psychosine Chemical Structure

CAS No. : 2238-90-6

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Description

Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].

IC50 & Target[2]

PKC

 

In Vitro

Psychosine, is a substrate of the GALC enzyme that shows promise to aid in the diagnosis and follow-up of at-risk infants identified through newborn screening (NBS)[1]. Psychosine induces pleiotropic effects, including dysfunctions in several cellular pathways[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Oligodendrocyte cells, M03.13
Concentration: 10, 20, and 40 μM
Incubation Time: 24 hours
Result: Caused cell death at least in part via apoptosis.
Molecular Weight

461.63

Formula

C₂₄H₄₇NO₇

CAS No.
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Product Name:
Psychosine
Cat. No.:
HY-136490
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