2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. SR1555

SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases.

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SR1555 Chemical Structure

SR1555 Chemical Structure

CAS No. : 1386439-51-5

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Based on 1 publication(s) in Google Scholar

SR1555 Related Antibodies

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Description

SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases[1].

IC50 & Target[1]

RORγ

1 μM (IC50)

In Vitro

SR1555 (10 μM; 24 h) inhibits Il17a gene expression by greater than 70%in EL4 cells[1].
SR1555 (10 μM; 24 h) inhibits IL-17 protein expression, inhibits TH17 cell differentiation and function, and does not induce cell death during TH17 cell differentiation[1].
SR1555 (10 μM; 24 h) effectively increases the gene expression of Foxp3 while simultaneously suppressing the gene expression of Rorγt[1].
SR1555 increases the frequency of T regulatory cells as evidenced by the almost 2-fold increase in the expression of Foxp3+ T cells in the splenocyte culture[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR1555 Related Antibodies

RT-PCR[1]

Cell Line: EL4 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Inhibited Il17a gene expression by greater than 70%.

Cell Differentiation Assay[1]

Cell Line: Splenocytes (cultured under TH17 polarizing conditions for 3 days)
Concentration: 10 μM
Incubation Time: 24 h
Result: Inhibited IL-17 protein expression, inhibited TH17 cell differentiation and function, and did not induce cell death during TH17 cell differentiation.

RT-PCR[1]

Cell Line: Splenocytes (cultured under T regulatory cell polarizing conditions for 3 days)
Concentration: 10 μM
Incubation Time: 24 h
Result: Effectively increased the gene expression of Foxp3 while simultaneously suppressing the gene expression of Rorγt.
Molecular Weight

460.41

Formula

C22H22F6N2O2
CAS No.
SMILES

CC(N1CCN(CC2=CC=C(C3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3)C=C2)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SR1555 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR15551386439-51-5SR 1555SR-1555RORRAR-related orphan receptorRORγTH17 cellsT regulatory cellsIL-17EL4 cellssplenocytesautoimmune diseasesInhibitorinhibitorinhibit

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