Izumerogant
Based on 1 Customer Validation
Izumerogant (IMU-935) is an orally active RORγ/DHODH dual inhibitor with IC50s of 10 and 98 nM against RORγ and DHODH. Izumerogant efficiently blocks the replication of SARS-CoV-2, HCMV and HAdV5 with EC50 values between 3.6 and 17 nM. Izumerogant can be used for researching antiviral properties.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 2299252-72-3
- Formula: C22H18ClF4N5O2
- Molecular Weight:495.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Metabolism/Protease Compound Library
HY-L012
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Clinical Compound Library
HY-L026
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Antiviral Compound Library
HY-L027
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Small Molecule Immuno-Oncology Compound Library
HY-L031
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Ferroptosis Compound Library
HY-L051
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Orally Active Compound Library
HY-L061
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Mitochondria-Targeted Compound Library
HY-L089
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Transcription Factor-Targeted Library
HY-L090
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Nuclear Receptor Compound Library
HY-L126
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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RORγ 10 nM (IC50) |
Izumerogant exhibits nanomolar inhibitory activity against SARS-CoV-2, HCMV and HAdV5 with EC50s of 3.6 nM, 17 nM and 12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2299252-72-3
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Appearance Solid
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Molecular Weight 495.86
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Formula C22H18ClF4N5O2
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Color Off-white to light brown
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SMILES
FC1=CC=CC(Cl)=C1C2=NOC(C3=C(C(F)(F)F)N(CCC(C)(C)O)N=C3)=C2C4=NC=CC=N4
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Synonyms
IMU-935
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (403.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[2]. Polasek TM, et al. Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study. Clin Pharmacol Drug Dev. 2023 May;12(5):525-534. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0167 mL | 10.0835 mL | 20.1670 mL | 50.4175 mL |
| 5 mM | 0.4033 mL | 2.0167 mL | 4.0334 mL | 10.0835 mL | |
| 10 mM | 0.2017 mL | 1.0083 mL | 2.0167 mL | 5.0417 mL | |
| 15 mM | 0.1344 mL | 0.6722 mL | 1.3445 mL | 3.3612 mL | |
| 20 mM | 0.1008 mL | 0.5042 mL | 1.0083 mL | 2.5209 mL | |
| 25 mM | 0.0807 mL | 0.4033 mL | 0.8067 mL | 2.0167 mL | |
| 30 mM | 0.0672 mL | 0.3361 mL | 0.6722 mL | 1.6806 mL | |
| 40 mM | 0.0504 mL | 0.2521 mL | 0.5042 mL | 1.2604 mL | |
| 50 mM | 0.0403 mL | 0.2017 mL | 0.4033 mL | 1.0083 mL | |
| 60 mM | 0.0336 mL | 0.1681 mL | 0.3361 mL | 0.8403 mL | |
| 80 mM | 0.0252 mL | 0.1260 mL | 0.2521 mL | 0.6302 mL | |
| 100 mM | 0.0202 mL | 0.1008 mL | 0.2017 mL | 0.5042 mL |
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