2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Anti-infection
  3. ROR Dihydroorotate Dehydrogenase SARS-CoV CMV
  4. Izumerogant

Izumerogant (IMU-935) is an orally active RORγ/DHODH dual inhibitor with IC50s of 10 and 98 nM against RORγ and DHODH. Izumerogant efficiently blocks the replication of SARS-CoV-2, HCMV and HAdV5 with EC50 values between 3.6 and 17 nM. Izumerogant can be used for researching antiviral properties.

For research use only. We do not sell to patients.

Izumerogant

Izumerogant Chemical Structure

CAS No. : 2299252-72-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Izumerogant:

Izumerogant Related Antibodies

Top Publications Citing Use of Products

View All ROR Isoform Specific Products:

View All Isoforms
RORγ RORα RORβ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Izumerogant (IMU-935) is an orally active RORγ/DHODH dual inhibitor with IC50s of 10 and 98 nM against RORγ and DHODH. Izumerogant efficiently blocks the replication of SARS-CoV-2, HCMV and HAdV5 with EC50 values between 3.6 and 17 nM. Izumerogant can be used for researching antiviral properties[1][2].

IC50 & Target[1]

RORγ

10 nM (IC50)

In Vitro

Izumerogant exhibits nanomolar inhibitory activity against SARS-CoV-2, HCMV and HAdV5 with EC50s of 3.6 nM, 17 nM and 12 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Izumerogant Related Antibodies
Parmacokinetics
Species Dose Route Note Cmax T1/2 AUC0-24
Mice[1] 5 mg/kg p.o. male 218 ng/mL 2.3 h 431 ng·h/mL
Mice[1] 5 mg/kg p.o. female 159 ng/mL 1.4 h 332 ng·h/mL
Clinical Trial
Molecular Weight

495.86

Formula

C22H18ClF4N5O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

FC1=CC=CC(Cl)=C1C2=NOC(C3=C(C(F)(F)F)N(CCC(C)(C)O)N=C3)=C2C4=NC=CC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (403.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0167 mL 10.0835 mL 20.1670 mL
5 mM 0.4033 mL 2.0167 mL 4.0334 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0167 mL 10.0835 mL 20.1670 mL 50.4175 mL
5 mM 0.4033 mL 2.0167 mL 4.0334 mL 10.0835 mL
10 mM 0.2017 mL 1.0083 mL 2.0167 mL 5.0417 mL
15 mM 0.1344 mL 0.6722 mL 1.3445 mL 3.3612 mL
20 mM 0.1008 mL 0.5042 mL 1.0083 mL 2.5209 mL
25 mM 0.0807 mL 0.4033 mL 0.8067 mL 2.0167 mL
30 mM 0.0672 mL 0.3361 mL 0.6722 mL 1.6806 mL
40 mM 0.0504 mL 0.2521 mL 0.5042 mL 1.2604 mL
50 mM 0.0403 mL 0.2017 mL 0.4033 mL 1.0083 mL
60 mM 0.0336 mL 0.1681 mL 0.3361 mL 0.8403 mL
80 mM 0.0252 mL 0.1260 mL 0.2521 mL 0.6302 mL
100 mM 0.0202 mL 0.1008 mL 0.2017 mL 0.5042 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Izumerogant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Izumerogant2299252-72-3IMU-935IMU935IMU 935RORDihydroorotate DehydrogenaseSARS-CoVCMVRAR-related orphan receptorDHODHSARS coronavirusCytomegalovirusHuman virusesHost-targeting antiviralDual-targetingsmall moleculesDHODH inhibitorRORγ inhibitorBroad-spectrum antiviralInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Izumerogant
Cat. No.:
HY-152851
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (254 KB) Français - FR (254 KB) Deutsch - DE (254 KB) Norwegian - NO (254 KB) Español - ES (254 KB) Swedish - SV (254 KB) Italian - IT (254 KB) Korean - KR (254 KB) Portuguese - PT (254 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.