γ-Glutamylvaline
Based on 1 Customer Validation
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation.
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- Pureté: 99.94%
- CAS No.: 2746-34-1
- Formule: C10H18N2O5
- Masse moléculaire:246.26
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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PPAR-γ |
IL-6 |
Wnt5A |
γ-Glutamylvaline (0.01-10 μM; 6 h) activates CaSR in differentiated 3T3-L1 mouse adipocytes, as measured by increased intracellular calcium fluorescence after 6 h of incubation[1].
γ-Glutamylvaline (1-100 μM; 24 h pretreatment, 24 h TNF-α exposure) significantly suppresses TNF-α-induced IL-6 and MCP-1 production and restores adiponectin levels in differentiated 3T3-L1 mouse adipocytes[1].
γ-Glutamylvaline (10 μM; 2 h) promotes the binding interaction between CaSR and β-arrestin 2 in differentiated 3T3-L1 mouse adipocytes[1].
γ-Glutamylvaline (10 μM; 2 h) upregulates Wnt5a gene expression and restores TNF-α-suppressed β-catenin phosphorylation in differentiated 3T3-L1 mouse adipocytes[1].
γ-Glutamylvaline (10 μM; 2 h pretreatment, 30 min TNF-α stimulation) counteracts TNF-α-induced downregulation of PPARγ1+2 in differentiated 3T3-L1 mouse adipocytes[1].
γ-Glutamylvaline (10 μM; 45 min insulin exposure, 2 h treatment, 30 min TNF-α stimulation) inhibits TNF-α-induced serine phosphorylation of IRS-1 in differentiated 3T3-L1 mouse adipocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:differentiated 3T3-L1 mouse adipocytes (TNF-α-induced inflammation model)
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Concentration:1, 10, 100 μM; 10 μM (IL-6 suppression); 10, 100 μM (MCP-1 suppression; adiponectin restoration)
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Incubation Time:24 h (pretreatment); 24 h (TNF-α exposure)
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Result:Suppressed TNF-α-induced IL-6 production to 23.92 ng/mL at 10 μM.
Suppressed TNF-α-induced MCP-1 production to 101.17 ng/mL and 120.36 ng/mL at 10 μM and 100 μM, respectively.
Restored adiponectin production to 7.37 ng/mL and 7.40 ng/mL at 10 μM and 100 μM, respectively.
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Cell Line:differentiated 3T3-L1 mouse adipocytes (TNF-α-induced model)
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Concentration:10 μM
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Incubation Time:2 h (pretreatment); 30 min (TNF-α stimulation)
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Result:Counteracted TNF-α-induced downregulation of PPARγ1/PPARγ2, increasing expression to 1.249 relative to β-actin at 10 μM.
This effect was reversed by pretreatment with the CaSR antagonist NPS-2143.
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Cell Line:differentiated 3T3-L1 mouse adipocytes
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Concentration:10 μM
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Incubation Time:45 min (insulin exposure); 2 h (γ-glutamylvaline treatment); 30 min (TNF-α stimulation)
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Result:Inhibited TNF-α-upregulated p-Ser-IRS1 expression to 1.89 relative to total IRS-1 at 10 μM.
Chemical Information
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CAS No. 2746-34-1
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Appearance Solid
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Masse moléculaire 246.26
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Formule C10H18N2O5
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Color White to off-white
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Synonyms
γ-Glu-Val
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
H2O : ≥ 100 mg/mL (406.07 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.0607 mL | 20.3037 mL | 40.6075 mL | 101.5187 mL |
| 5 mM | 0.8121 mL | 4.0607 mL | 8.1215 mL | 20.3037 mL | |
| 10 mM | 0.4061 mL | 2.0304 mL | 4.0607 mL | 10.1519 mL | |
| 15 mM | 0.2707 mL | 1.3536 mL | 2.7072 mL | 6.7679 mL | |
| 20 mM | 0.2030 mL | 1.0152 mL | 2.0304 mL | 5.0759 mL | |
| 25 mM | 0.1624 mL | 0.8121 mL | 1.6243 mL | 4.0607 mL | |
| 30 mM | 0.1354 mL | 0.6768 mL | 1.3536 mL | 3.3840 mL | |
| 40 mM | 0.1015 mL | 0.5076 mL | 1.0152 mL | 2.5380 mL | |
| 50 mM | 0.0812 mL | 0.4061 mL | 0.8121 mL | 2.0304 mL | |
| 60 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6920 mL | |
| 80 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2690 mL | |
| 100 mM | 0.0406 mL | 0.2030 mL | 0.4061 mL | 1.0152 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
γ-Glutamylvaline Related Classifications
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