2746-34-1
Chemical Structure
γ-Glutamylvaline
Synonym(s): γ-Glu-Val
- CAS No.: 2746-34-1
- Formula:C10H18N2O5
- Molecular Weight:246.26
IUPAC Name: N5-((S)-1-carboxy-2-methylpropyl)-L-glutamine
InChIKey: AQAKHZVPOOGUCK-XPUUQOCRSA-N
SMILES: CC([C@@H](C(O)=O)NC(CC[C@H](N)C(O)=O)=O)C
Biological Activity: γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation[1].
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γ-Glutamylvaline | 99.94% | γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation. | ||||||||||||||||||||
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Keywords
