L-gamma-Glutamyl-L-threonine (Synonyms: gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr)

Cat. No.: HY-N13356 Purity: 99.97%: Data Sheet
COA

SDS
Handling Instructions
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L-gamma-Glutamyl-L-threonine (gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr) is a dipeptide obtained through the formal condensation of the L-glutamic acid side chain carboxyl group and the L-threonine amino group. L-gamma-Glutamyl-L-threonine is present in high concentrations in human urine and exhibits antibacterial activity against Gram-negative bacterial. L-gamma-Glutamyl-L-threonine is also a flavor compound. Gamma-Glutamylthreonine is a metabolite catalyzed by γ-glutamyl transpeptidase and is associated with immune regulation. Gamma-Glutamylthreonine can be used in research on inflammation and bacterial infections.

For research use only. We do not sell to patients.

L-gamma-Glutamyl-L-threonine Chemical Structure

CAS No. : 5652-48-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

In Vitro

L-gamma-Glutamyl-L-threonine (Compound 8) (450-1800 μmol/L) has a taste recognition threshold of 900 μmol/L in bottled water at pH 5.3, and produces a non-specific, slight astringent oral sensation^[2].
L-gamma-Glutamyl-L-threonine contributes to the kokumi flavor of water-soluble Parmesan cheese WSE matrix, and the kokumi intensity decreases from 2.2 to 1.3 after the removal of this substance^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.23

Formula

C₉H₁₆N₂O₆

CAS No.

5652-48-2

Appearance

Solid

Color

White to off-white

Sequence

γ-Glu-Thr

Sequence Shortening

γ-ET

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (402.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0285 mL	20.1426 mL	40.2852 mL
5 mM	0.8057 mL	4.0285 mL	8.0570 mL
10 mM	0.4029 mL	2.0143 mL	4.0285 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (246 KB) RP-HPLC (241 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. The effect of inflammatory proteins on COVID-19 is mediated by blood metabolites: A Mendelian randomization study. Medicine (Baltimore). 2025 Mar 14;104(11):e41852. [Content Brief]

[2]. Hillmann H, et al. Quantitation of Key Tastants and Re-engineering the Taste of Parmesan Cheese. J Agric Food Chem. 2016;64(8):1794-1805.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0285 mL	20.1426 mL	40.2852 mL	100.7131 mL
	5 mM	0.8057 mL	4.0285 mL	8.0570 mL	20.1426 mL
	10 mM	0.4029 mL	2.0143 mL	4.0285 mL	10.0713 mL
	15 mM	0.2686 mL	1.3428 mL	2.6857 mL	6.7142 mL
	20 mM	0.2014 mL	1.0071 mL	2.0143 mL	5.0357 mL
	25 mM	0.1611 mL	0.8057 mL	1.6114 mL	4.0285 mL
	30 mM	0.1343 mL	0.6714 mL	1.3428 mL	3.3571 mL
	40 mM	0.1007 mL	0.5036 mL	1.0071 mL	2.5178 mL
	50 mM	0.0806 mL	0.4029 mL	0.8057 mL	2.0143 mL
	60 mM	0.0671 mL	0.3357 mL	0.6714 mL	1.6786 mL
	80 mM	0.0504 mL	0.2518 mL	0.5036 mL	1.2589 mL
	100 mM	0.0403 mL	0.2014 mL	0.4029 mL	1.0071 mL

L-gamma-Glutamyl-L-threonine Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-gamma-Glutamyl-L-threonine5652-48-2gamma-Glutamylthreonine H-γ-Glu-Thr-OH γ-Glu-ThrBacterialPeptide-Drug Conjugates (PDCs)Drug MetabolitedipeptidebacterialInhibitorinhibitorinhibit

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L-gamma-Glutamyl-L-threonine (Synonyms: gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr)

L-gamma-Glutamyl-L-threonine Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

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References

Customer Review

L-gamma-Glutamyl-L-threonine Related Antibodies

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