2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Wnt
  5. Wnt5 Isoform
  6. Wnt5 Activator

Wnt5 Activator

Wnt5 Activator (1):

Cat. No. Product Name Effect Purity
  • HY-12557
    γ-Glutamylvaline
    		Activator 99.94%
    γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation.