1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. NUCC-390 dihydrochloride

NUCC-390 dihydrochloride 

Cat. No.: HY-111793A Purity: 99.59%
Handling Instructions

NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo.

For research use only. We do not sell to patients.

NUCC-390 dihydrochloride Chemical Structure

NUCC-390 dihydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 361 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1]. NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo[2].

IC50 & Target[1]

CXCR4

 

In Vitro

NUCC-390 dihydrochloride (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1].
NUCC-390 dihydrochloride (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].
NUCC-390 dihydrochloride (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].
NUCC-390 dihydrochloride (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: C8161 cells
Concentration: 10 μM
Incubation Time: Pre-treated 30 mins
Result: Increased the level of pERK.

Cell Proliferation Assay[2]

Cell Line: Cerebellar granule neurons (CGNs)
Concentration: 0 μM; 0.0625 μM; 0.25 μM; 1.25 μM
Incubation Time: 24 hours
Result: Stimulated axonal growth via CXCR4.
In Vivo

NUCC-390 dihydrochloride (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six to eight-week-old CD1 mice[2]
Dosage: 3.2 mg/kg
Administration: Hind limb injection; twice daily; 3 days
Result: Promoted functional and anatomical recovery of the NMJ.
Molecular Weight

468.46

Formula

C₂₃H₃₅Cl₂N₅O

SMILES

O=C(N1CCCCC1)C2=NN(CCC)C3=C2CC(NCCC4=CC=NC=C4)CC3.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (533.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1347 mL 10.6733 mL 21.3465 mL
5 mM 0.4269 mL 2.1347 mL 4.2693 mL
10 mM 0.2135 mL 1.0673 mL 2.1347 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NUCC-390NUCC390NUCC 390CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR4internalization(Ca)i responseC8161HEK293neurodegenerationneuroregenerationneuromuscular junctionmotorCGNsInhibitorinhibitorinhibit

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NUCC-390 dihydrochloride
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HY-111793A
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