1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. NUCC-390

NUCC-390 

Cat. No.: HY-111793
Handling Instructions

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo.

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NUCC-390 Chemical Structure

NUCC-390 Chemical Structure

CAS No. : 1060524-97-1

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Description

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1][2]. NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo[2].

IC50 & Target[1]

CXCR4

 

In Vitro

NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1].
NUCC-390 (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].
NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].
NUCC-390 (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4[2].

Western Blot Analysis[1]

Cell Line: C8161 cells 
Concentration: 10 μM
Incubation Time: Pre-treated 30 mins
Result: Increased the level of pERK.

Cell Proliferation Assay[2]

Cell Line: Cerebellar granule neurons (CGNs)
Concentration: 0 μM; 0.0625 μM; 0.25 μM; 1.25 μM
Incubation Time: 24 hours
Result: Stimulated axonal growth via CXCR4.
In Vivo

NUCC-390 (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice[2].

Animal Model: Six to eight-week-old CD1 mice[2]
Dosage: 3.2 mg/kg
Administration: Hind limb injection; twice daily; 3 days
Result: Promoted functional and anatomical recovery of the NMJ.
Molecular Weight

395.54

Formula

C₂₃H₃₃N₅O

CAS No.

1060524-97-1

SMILES

O=C(N1CCCCC1)C2=NN(CCC)C3=C2CC(NCCC4=CC=NC=C4)CC3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NUCC-390NUCC390NUCC 390CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR4internalization(Ca)i responseC8161HEK293neurodegenerationneuroregenerationneuromuscular junctionmotorCGNsInhibitorinhibitorinhibit

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