1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. NUCC-390

NUCC-390 

Cat. No.: HY-111793
Handling Instructions

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors.

For research use only. We do not sell to patients.

NUCC-390 Chemical Structure

NUCC-390 Chemical Structure

CAS No. : 1060524-97-1

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Description

NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors[1].

IC50 & Target

CXCR4

 

In Vitro

NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1].
NUCC-390 (10 μM) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1].
NUCC-390 exhibited the ability to induce CXCR4 receptor internalization, we assessed the cellular localization of YFP-tagged CXCR4 receptors expressed in HEK293 cells following treatment with SDF-1 or NUCC-390[1].
NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non--treated cells exhibits some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1].

Western Blot Analysis[1]

Cell Line: C8161 cells 
Concentration: 10 μM
Incubation Time:
Result: Increased the level of pERK[1].
Molecular Weight

395.54

Formula

C₂₃H₃₃N₅O

CAS No.

1060524-97-1

SMILES

O=C(N1CCCCC1)C2=NN(CCC)C3=C2CC(NCCC4=CC=NC=C4)CC3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NUCC-390NUCC390NUCC 390CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR4internalizationInhibitorinhibitorinhibit

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