1060524-97-1
1060524-97-1
Chemical Structure
NUCC-390
- CAS No.: 1060524-97-1
- Formula:C23H33N5O
- Molecular Weight:395.54
IUPAC Name: piperidin-1-yl(1-propyl-5-((2-(pyridin-4-yl)ethyl)amino)-4,5,6,7-tetrahydro-1H-indazol-3-yl)methanone
InChIKey: QUEIKILOAGDRRO-UHFFFAOYSA-N
SMILES: O=C(N1CCCCC1)C2=NN(CCC)C3=C2CC(NCCC4=CC=NC=C4)CC3
Biological Activity: NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046)[1][2]. NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NUCC-390 | 98.01% | NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo. | ||||||||||||||||||||
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References
- [1]. Mishra RK, et al. Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists.Sci Rep. 2016 Jul 26;6:30155. [Content Brief]
- [2]. Negro S, et al. An Agonist of the CXCR4 Receptor Strongly Promotes Regeneration of Degenerated Motor Axon Terminals.Cells. 2019 Sep 30;8(10). pii: E1183. [Content Brief]
