HL82624

Cat. No.: HY-183994: Data Sheet Handling Instructions
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HL82624 is a CXCR4 agnoist. HL82624 triggers CXCR4-mediated cell migration. HL82624 can be used for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

HL82624 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

HL82624 is a CXCR4 agnoist. HL82624 triggers CXCR4-mediated cell migration. HL82624 can be used for the research of neurodegenerative diseases^[1].

IC₅₀ & Target^[1]

CXCR4

In Vitro

HL82624 reduces CXCR4 activation energy barriers for all transition states, and facilitates early-stage CXCR4 activation^[1].
HL82624 binds to CXCR4 on Sup-T1 cells with an IC₅₀ of 24 μM^[1].
HL82624 (1-100 μM; 3 h) promotes CXCR4-mediated cell migration in Sup-T1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:	Sup-T1 cells
Concentration:	1; 10; 50; 100 μM
Incubation Time:	3 h
Result:	Showed maximal activity observed at 10-50 μM. Promoted CXCR4-mediated cell migration.

Molecular Weight

665.83

Formula

C₃₃H₅₁N₁₁O₄

SMILES

NC(NCCC[C@H](NCC1=CC=CC=N1)C(NCC2=CC(C[C@H](NC([C@H]3N(C([C@@H](N)CCCCN)=O)CCC3)=O)C(N)=O)=CC=C2)=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou J, et al. Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists. J Am Chem Soc. 2026;148(20):20545-20554.

HL82624 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HL82624HL 82624HL-82624CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsSup-T1 cellsE288W9412G5 antibodyCXCR4neurodegenerative diseasesInhibitorinhibitorinhibit

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