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Cat. No.: HY-183994

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HL82624

HL82624 is a CXCR4 agnoist. HL82624 triggers CXCR4-mediated cell migration. HL82624 can be used for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

Formula: C₃₃H₅₁N₁₁O₄
Molecular Weight:665.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HL82624 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

HL82624 is a CXCR4 agnoist. HL82624 triggers CXCR4-mediated cell migration. HL82624 can be used for the research of neurodegenerative diseases^[1].

IC₅₀ & Target^[1]

CXCR4

All CXCR Isoforms :

In Vitro

HL82624 reduces CXCR4 activation energy barriers for all transition states, and facilitates early-stage CXCR4 activation^[1].
HL82624 binds to CXCR4 on Sup-T1 cells with an IC₅₀ of 24 μM^[1].
HL82624 (1-100 μM; 3 h) promotes CXCR4-mediated cell migration in Sup-T1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

Sup-T1 cells
Concentration:

1; 10; 50; 100 μM
Incubation Time:

3 h
Result:

Showed maximal activity observed at 10-50 μM.
Promoted CXCR4-mediated cell migration.

Chemical Information

Molecular Weight 665.83
Formula C₃₃H₅₁N₁₁O₄
SMILES

NC(NCCC[C@H](NCC1=CC=CC=N1)C(NCC2=CC(C[C@H](NC([C@H]3N(C([C@@H](N)CCCCN)=O)CCC3)=O)C(N)=O)=CC=C2)=O)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou J, et al. Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists. J Am Chem Soc. 2026;148(20):20545-20554. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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