1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. CXCR4 antagonist 5

CXCR4 antagonist 5 

Cat. No.: HY-146372
Handling Instructions

CXCR4 antagonist 5 (compound 23) is a highly potent CXCR4 antagonist with an IC50 value of 8.8 nM. CXCR4 antagonist 5 can inhibit CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and inhibits CXCR4/CXLC12-mediated chemotaxis. CXCR4 antagonist 5 has good physicochemical properties and in vitro safety profiles, inhibiting CYP isozymes and hERG marginally or moderately.

For research use only. We do not sell to patients.

CXCR4 antagonist 5 Chemical Structure

CXCR4 antagonist 5 Chemical Structure

CAS No. : 2304749-86-6

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Description

CXCR4 antagonist 5 (compound 23) is a highly potent CXCR4 antagonist with an IC50 value of 8.8 nM. CXCR4 antagonist 5 can inhibit CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and inhibits CXCR4/CXLC12-mediated chemotaxis. CXCR4 antagonist 5 has good physicochemical properties and in vitro safety profiles, inhibiting CYP isozymes and hERG marginally or moderately[1].

IC50 & Target[1]

CXCR4

8.8 nM (IC50)

Molecular Weight

366.50

Formula

C21H30N6

CAS No.
SMILES

CC1=NC(N2CCN(CC2)C)=CC(CN([[email protected]@H]3C4=C(C=CC=N4)CCC3)C)=N1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
CXCR4 antagonist 5
Cat. No.:
HY-146372
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