CXCR4 antagonist 7
CXCR4 antagonist 7 (Compound PARA-B) is a CXCR4 antagonist with the IC50 of 9.3 nM. CXCR4 antagonist 7 can be used for the research of HIV infection, inflammatory diseases, cancer, and WHIM syndrome.
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- CAS. Nr.: 1185451-72-2
- Formel: C15H17N5O3
- Molecular Weight:315.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
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CXCR4/CXCL12 9.3 nM (IC50) |
In Vitro
CXCR4 antagonist 7 (PARA-B, 10 nM-1 μM, 20 h) inhibits CXCL12-induced GH4C1 cell proliferation with an IC50 value of 9.3 nM[1]. CXCR4 antagonist 7 (1 μM, 12 h) inhibits CXCL12-dependent GH4C1 cell migration with inhibition rate of 50%[1]. CXCR4 antagonist 7 (50 nM, 30 min) reduces ERK1/2 phosphorylation induced by CXCL12[1]. CXCR4 antagonist 7 (50 nM-1 μM, 30 min) acts via CXCR4 antagonism to revert CXCL12 induction of GH4C1 proliferation and migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GH4C1 cell (48 h of serum deprivation)
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Concentration:1 μM
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Incubation Time:24 h
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Result:Had no effect on cell viability of GH4C1 cell.
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Cell Line:GH4C1 cell ( FBS-starved GH4C1 cells treated with CXCL12 (25 nM) for 12 h)
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Concentration:10 nM-1 μM
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Incubation Time:20 h, 24 h
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Result:Inhibited proliferation of multiple cancer cell lines with IC50 value ranging from 1.08 to 3.45 μM, and had no effect on cell viability of GH4C1cell.
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Cell Line:GH4C1 and GH4A11 cells (FBS-starved cells treated with CXCL12 (25 nM) for 48 h)
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Concentration:50 nM-1 μM
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Incubation Time:12 h for GH4C1, 30 min for GH4A11
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Result:Reduced the number of migrating GH4C1 cells significantly, had no effect on GH4A11 cell (CRISPR-CAS9, reduction in CXCR4 mRNA) migration.
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Cell Line:GH4C1 cell (FBS-starved cells treated with CXCL12 (25 nM) for 15 min)
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Concentration:50 nM
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Incubation Time:30 min
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Result:Reduced ERK1/2 phosphorylation induced by CXCL12.
Chemical Information
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CAS. Nr. 1185451-72-2
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Molecular Weight 315.33
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Formel C15H17N5O3
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SMILES
O=C(N(C(N/1)=O)/C=C/C2=CC=C(O)C=C2)C1=C\CC/N=C(N)/N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CXCR4 antagonist 7 Related Classifications
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